Decreased perfusion in the lateral wall of the left ventricle in PET/CT studies with 13N-ammonia: evaluation in healthy adults

Journal of Nuclear Medicine Technology
William C KlingensmithSpero M Manson

Abstract

This study evaluated the causes of the frequently observed decreased myocardial perfusion in the lateral wall of the left ventricle in PET/CT studies with (13)N-ammonia in healthy adults. Thirty-two adults who were undergoing PET/CT of the heart with (13)N-ammonia as part of a study of the effects of posttraumatic stress disorder in American Indians were included. Participants who had evidence of heart disease by a physician-administered questionnaire or by pharmacologic stress during the myocardial perfusion study were excluded. The ratio of counts in the lateral wall relative to the septum at stress and rest were compared with the degree of misalignment between the PET and CT images at the left border of the heart and at the right hemidiaphragm. No participant had evidence of heart disease. For the left heart border, 41% of participants showed misalignment at rest and 62% showed misalignment at stress. For the right hemidiaphragm, 28% showed misalignment at rest and 53% showed misalignment at stress. Among all participants, the decrease in lateral wall counts relative to the septum correlated with the degree of misalignment of the PET and CT images at the left heart border at rest using both average (P = 0.01) and maximum (P ...Continue Reading

Citations

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