PMID: 2506496Aug 14, 1989Paper

Decreased peroxidative potential in rat brain microsomal fractions during ageing

Neuroscience Letters
T P Devasagayam

Abstract

Rough and smooth microsomes of brain in senescent rats showed less sensitivity to ascorbate-, NADPH- and cumene hydroperoxide-induced peroxidative damage compared with those of young adults. The observed decrease in peroxidative potential in senescent rats seemed to be due to decrease in the substrate for peroxidation in the form of phospholipids and increase in the level of antioxidants such as reduced glutathione and superoxide dismutase.

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Citations

Jul 1, 1995·Neurobiology of Aging·G Benzi, A Moretti
Jan 1, 1995·Neurobiology of Aging·M Cini, A Moretti
Jun 1, 1992·Progress in Neurobiology·C P LeBel, S C Bondy
Mar 1, 1994·Progress in Neurobiology·J W Phillis
Jun 11, 1993·Neuroscience Letters·M SubramanianT P Devasagayam
Jan 1, 1991·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·C P LeBel, S C Bondy
May 1, 1991·Neurotoxicology and Teratology·C P LeBel, S C Bondy
Oct 14, 2004·Redox Report : Communications in Free Radical Research·Jai C TilakThomas P A Devasagayam
Jan 1, 1993·Brain Research. Brain Research Reviews·R A Grünewald

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