Decreased peroxisome proliferator-activated receptor γ level and signalling in sebaceous glands of patients with acne vulgaris

Clinical and Experimental Dermatology
Anikó DózsaLaszlo Nagy

Abstract

Little is known about the altered lipid metabolism-related transcriptional events occuring in sebaceous glands of patients with acne vulgaris. Peroxisome proliferator-activated receptor (PPAR)γ, a lipid-activated transcription factor, is implicated in differentiation and lipid metabolism of sebocytes. We have observed that PPARγ and its target genes, ADRP (adipose differentiation related protein) and PGAR (PPARγ angioprotein related protein) are expressed at lower levels in sebocytes from patients with acne than in those from healthy controls (HCs) Furthermore, endogenous PPARγ activator lipids such as arachidonic acid-derived keto-metabolites (e.g. 5KETE, 12KETE) are increased in acne-involved and nonacne-involved skin of patients with acne, compared with skin from healthy individuals. Our findings highlight the possible anti-inflammatory role of endogenous ligand-activated PPARγ signaling in human sebocyte biology, and suggest that modulating PPARγ- expression and thereby signaling might be a promising strategy for the clinical management of acne vulgaris.

References

Jun 1, 1997·International Journal of Dermatology·A DoshiM J Stiller
Jan 3, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Theodosios AlestasChristos C Zouboulis
May 6, 2006·The Journal of Investigative Dermatology·Nishit R TrivediDiane M Thiboutot
Jun 16, 2010·Experimental Dermatology·Arianna MastrofrancescoMauro Picardo
Aug 24, 2013·Journal of Vascular Research·Monika SzklenarRalph Rühl
Oct 30, 2013·The Journal of Investigative Dermatology·Arianna MastrofrancescoMauro Picardo
Dec 7, 2013·Skin Pharmacology and Physiology·M A Sieber, J K E Hegel

❮ Previous
Next ❯

Citations

Mar 28, 2018·Experimental Dermatology·Ewan A LanganRalf Paus
May 31, 2018·Current Opinion in Pediatrics·Muithi Mwanthi, Andrea L Zaenglein
Oct 13, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jean-Francois LandrierRalph Rühl
Jan 31, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·M OttavianiM Picardo
Aug 12, 2020·Experimental Dermatology·Stefania BrigantiMonica Ottaviani
Nov 27, 2019·Experimental Dermatology·Yuval RamotRalf Paus
Oct 22, 2020·Nature Communications·Bénédicte OulèsFiona M Watt
Aug 12, 2020·Experimental Dermatology·Christos C Zouboulis
May 4, 2017·Biochemical Pharmacology·A MastrofrancescoM Picardo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.