Decreased pituitary response to insulin-induced hypoglycaemia in young lean male patients with essential hypertension

Journal of Human Hypertension
Z RadikovaJuraj Koska

Abstract

Essential hypertension is associated with changes in central catecholaminergic pathways which might also be reflected in the pituitary response to stress stimuli. The aim of this study was to determine whether the response of pituitary hormones, cortisol, plasma renin activity, aldosterone and catecholamines to insulin-induced hypoglycaemia is changed in hypertension. We studied 22 young lean male patients with newly diagnosed untreated essential hypertension and 19 healthy normotensive, age- and body mass index (BMI)-matched controls. All subjects underwent an insulin tolerance test (0.1 IU insulin/kg body weight intravenously) with blood sampling before and 15, 30, 45, 60 and 90 min after insulin administration. Increased baseline levels of norepinephrine (P<0.05), increased response of norepinephrine (P<0.001) and decreased response of growth hormone (P<0.001), prolactin (P<0.001), adrenocorticotropic hormone (P<0.05) and cortisol (P<0.001) were found in hypertensive patients when compared to normotensive controls. Increased norepinephrine levels and a decreased pituitary response to metabolic stress stimuli may represent another manifestation of chronically increased sympathetic tone in early hypertension.

References

Aug 1, 1990·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·A GiustinaG Romanelli
May 1, 1989·Clinical Endocrinology·J Alba-RothK von Werder
Jan 1, 1989·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R C CuneoR A Donald
Jun 1, 1995·Hypertension Research : Official Journal of the Japanese Society of Hypertension·J Amerena, S Julius
Jul 12, 1995·Annals of the New York Academy of Sciences·G W LambertM D Esler
Apr 1, 1993·Baillière's Clinical Endocrinology and Metabolism·S al-Damluji
Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·M J HayesJ M Hughes
Apr 30, 1999·Physiological Reviews·E E MüllerD Cocchi
Jul 28, 1999·Clinical and Experimental Hypertension : CHE·S Julius
Sep 29, 1999·Endocrinology and Metabolism Clinics of North America·G B Bolli, C G Fanelli
May 3, 2002·Journal of Human Hypertension·V DeQuattro, M Feng
Oct 16, 2002·Journal of Psychosomatic Research·Constantine Tsigos, George P Chrousos
Feb 26, 2003·European Journal of Pharmacology·Gonzalo A Carrasco, Louis D Van de Kar
Jun 5, 2003·Journal of Hypertension·UNKNOWN European Society of Hypertension-European Society of Cardiology Guidelines Committee
Jun 14, 2003·Brain : a Journal of Neurology·Yudith AvnonDavid Yarnitsky
Dec 25, 2003·Diabetes Care·UNKNOWN American Diabetes Association
Feb 19, 2004·American Journal of Physiology. Endocrinology and Metabolism·Michael A DeRosa, Philip E Cryer
Dec 14, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Daniela JezovaMartin Jakubek
May 18, 2005·Hypertension·Laura P Svetkey
Jun 7, 2005·Journal of the American Society of Nephrology : JASN·Giuseppe ManciaUNKNOWN European Society of Cardiology

❮ Previous
Next ❯

Citations

Jul 16, 2010·Journal of Human Hypertension·A PenesovaZ Radikova
Jan 6, 2009·Annals of the New York Academy of Sciences·Adela PenesovaMilan Vigas
Aug 24, 2006·Physiological Genomics·Fabiana Sant'Anna Evangelista, José E Krieger
Feb 12, 2020·Trends in Endocrinology and Metabolism : TEM·Yazmín MacotelaCarmen Clapp

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.