Decreased plasma antioxidants in patients with Alzheimer's disease

International Journal of Geriatric Psychiatry
Tae-Suk KimChang-Uk Lee

Abstract

It has been suggested that oxidative injuries have an important role in the pathogenesis of Alzheimer's disease (AD). In this study, we assess whether the plasma levels of albumin, bilirubin, and uric acid would be altered in the AD patients compared to those of the healthy controls. Furthermore, we tried to find the correlations between plasma antioxidant levels and the cognitive function in AD patients. The plasma albumin, bilirubin, and uric acid levels were measured by standard methods in 101 AD patients and 101 healthy controls. The Korean version of the Mini Mental Status Examination (MMSE-K) was used to evaluate the cognitive functions of AD patients. A significant reduction in the albumin, bilirubin, and uric acid levels in the AD group was found compared to those of the control group. The scores of MMSE-K showed the positive correlation with albumin level in the AD group after adjusting confounding factors such as body mass index, gender and age. This study showed that oxidative injuries could be involved in the pathogenesis of AD, as well as indicating that some antioxidant might be associated with the cognitive functions in AD.

References

Dec 1, 1991·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·T W WuH Sugiyama
Jul 1, 1990·Journal of Neurochemistry·K V SubbaraoL C Ang
Aug 13, 1988·BMJ : British Medical Journal·S SinghM S Losowsky
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R Stocker, B N Ames
Nov 1, 1971·The American Journal of Physiology·E A Rodriguez Garay, O U Scremin
Jan 1, 1971·Clinica Chimica Acta; International Journal of Clinical Chemistry·B T DoumasH G Biggs
Jun 1, 1971·Journal of the Neurological Sciences·K G Kjellin
Oct 29, 1993·Science·J T Coyle, P Puttfarcken
Jan 1, 1993·Alzheimer Disease and Associated Disorders·D M High
Jun 1, 1993·Free Radical Biology & Medicine·B F Becker
Aug 1, 1996·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R D Reddy, J K Yao
Feb 16, 1999·Brain Pathology·W R Markesbery, J M Carney
Oct 29, 1999·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·A M Papas
Oct 19, 2000·Journal of the American Geriatrics Society·C BerrA Alpérovitch
Feb 13, 2001·Psychiatry Research·J K YaoD P van Kammen
Jan 10, 2004·Advances in Experimental Medicine and Biology·Wulf Dröge
Mar 25, 2004·Lancet Neurology·Xiongwei ZhuMark A Smith
May 5, 2004·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·H Fai PoonD Allan Butterfield

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Citations

Dec 4, 2010·Antioxidants & Redox Signaling·Jeffrey K Yao, Matcheri S Keshavan
Nov 28, 2008·Brain : a Journal of Neurology·S M EuserMonique M B Breteler
Jul 16, 2010·Rheumatology·Bonifacio Álvarez-Lario, Jesús Macarrón-Vicente
Oct 9, 2007·Current Opinion in Psychiatry·Helen Fung-Kum ChiuLinda Chiu-Wa Lam
Dec 11, 2008·Neuro-degenerative Diseases·Michael C IrizarryPaul S Aisen
Jun 11, 2011·American Journal of Nephrology·Baris AfsarMehmet Kanbay
Mar 8, 2013·Neuro-degenerative Diseases·Nikolaus R McFarlandMichael A Schwarzschild
Oct 29, 2010·International Journal of Alzheimer's Disease·Orest HurkoDaniel Crowther
Jan 1, 2014·Rheumatology International·Anna L GoslingTony R Merriman
Sep 19, 2014·Analytical and Bioanalytical Chemistry·R González-DomínguezJ L Gómez-Ariza
Sep 13, 2011·QJM : Monthly Journal of the Association of Physicians·B Alvarez-Lario, J Macarrón-Vicente
Jun 21, 2014·BioMed Research International·Ya-Ting ChangCheng-Hsien Lu
Aug 25, 2015·Neuroscience Letters·Huihui JiQinwen Wang
Jul 23, 2015·Molecular Neurobiology·Ewa NiedzielskaMałgorzata Filip
Jul 6, 2014·Internal and Emergency Medicine·Arrigo Francesco Giuseppe CiceroUNKNOWN Brisighella Heart Study Group
Sep 9, 2016·Clinical and Experimental Otorhinolaryngology·Hui-Fang YangWei-Liang Chen
Feb 17, 2017·Dementia and Geriatric Cognitive Disorders Extra·Kazushi SuzukiAtsushi Iwata
Jun 28, 2016·PloS One·Massimo VenturelliFabio Esposito
Jun 1, 2017·International Journal of Molecular Sciences·Kelsey E Murphy, Joshua J Park
Feb 14, 2014·Journal of the American Geriatrics Society·Amir I A AhmedFrans M E van Schendel
Dec 23, 2016·Liver International : Official Journal of the International Association for the Study of the Liver·Silvia GazzinClaudio Tiribelli
Jun 21, 2017·Dementia and Geriatric Cognitive Disorders·Puneet TalwarRitushree Kukreti
Dec 18, 2013·Angiology·Yavuzer KozaEsma Selva Ates
Sep 20, 2015·American Journal of Alzheimer's Disease and Other Dementias·Min YuanXiaoping Yin
Dec 12, 2017·Journal of Nutrition and Metabolism·Rondo P MiddletonJim Kaput
Jul 2, 2015·Molecular BioSystems·Raúl González-DomínguezJosé Luis Gómez-Ariza
Aug 20, 2014·Electrophoresis·Raúl González-DomínguezJosé Luis Gómez-Ariza
Oct 21, 2017·Chinese Medical Journal·UNKNOWN Multidisciplinary Expert Task Force on Hyperuricemia and Related Diseases
May 29, 2015·Arthritis Research & Therapy·Jen-Yee HongHsiao-Yi Lin
Jul 26, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Kayla N GreenGiridhar Akkaraju

❮ Previous
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