Decreased plasma folate concentration in young and elderly healthy subjects after a short-term supplementation with isotretinoin

Journal of the European Academy of Dermatology and Venereology : JEADV
A ChansonP Brachet

Abstract

In the last two decades, there has been an increasing use of isotretinoin (13-cis-retinoic acid or 13-CRA) for treatment of severe, and recently mild and moderate, acne in Westernized populations. Recent human and animal studies emphasized alterations caused by 13-CRA administration on folate-dependent, one-carbon metabolism. Folate deficiency and subsequent hyperhomocysteinemia increase the risk of degenerative diseases. We determine whether a short-term supplementation with 13-CRA alters folate status and homocysteinemia in young and elderly healthy human subjects. Twenty young and 20 elderly (age mean, 26.1 and 65.4 years, respectively) healthy male volunteers were supplemented with approximately 0.5 mg/kg/day of 13-CRA for 28 days. Fasting plasma concentrations of 13-CRA, 5-methyltetrahydrofolate (5-mTHF) as the main circulating form of folate, and homocysteine (Hcy), as well as haematologic parameters and biochemical markers of liver and renal function, were measured at baseline and at the end of supplementation. Statistical analyses were carried out using two-way anova and standard tests. In both groups, isotretinoin supplementation caused a dramatic increase in the circulating concentration of 13-CRA and its derivatives....Continue Reading

References

Mar 1, 1992·Journal of Clinical Epidemiology·M E SaliveR B Wallace
May 1, 1985·Human Toxicology·J R MarsdenJ D Dennis
Aug 1, 1982·The British Journal of Dermatology·S Gutschmidt, D Tsambaos
Apr 16, 1999·The Journal of Nutrition·L B Bailey, J F Gregory
Jun 1, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J A van OersE F van Bommel
Mar 30, 2001·International Journal of Dermatology·K H SchulpisS Tsakiris
Dec 18, 2001·Diabetes/metabolism Research and Reviews·H A KoistinenP Ebeling
Mar 7, 2002·The Journal of Nutrition·Matthew J RowlingKevin L Schalinske
Mar 22, 2002·Journal of the American Academy of Dermatology·Diane K WysowskiAmarilys Vega
Jun 11, 2002·Archives of Biochemistry and Biophysics·Mary H McMullenKevin L Schalinske
Sep 5, 2002·BMJ : British Medical Journal·Tom Poyner, Bill Cunliffe
May 29, 2004·Current Opinion in Lipidology·Anne M Molloy
Jul 13, 2004·Mechanisms of Ageing and Development·Rachel E B WatsonChristopher E M Griffiths
Apr 16, 2005·The Proceedings of the Nutrition Society·Susan J DuthieHilary Powers
Aug 23, 2006·Nature Reviews. Neuroscience·Henk J BlomRichard H Finnell
Aug 26, 2006·Birth Defects Research. Part A, Clinical and Molecular Teratology·Emmanuel RatFranck Broly
Jun 1, 2004·Nutrition Research Reviews·Patrick BrachetEdmond Rock

❮ Previous
Next ❯

Citations

Sep 10, 2011·The Journal of Clinical Psychiatry·J Douglas BremnerPeter J McCaffery
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·M Elizabeth Ross
Aug 17, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·T-Y TsaiY-C Huang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Tan Pham, R Hal Scofield
Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery
Henrique T R de OliveiraDaniela N Silva
Annales de dermatologie et de vénéréologie
C Léauté-LabrèzeA Taieb
© 2021 Meta ULC. All rights reserved