May 8, 2020

Decreased Plasma Maresin 1 Concentration Is Associated with Diabetic Foot Ulcer

Mediators of Inflammation
Tian MiaoHua Qu

Abstract

To assess the maresin 1 (MaR1) contents in type 2 diabetic patients with or without diabetic foot ulcer and to analyze the association of MaR1 concentrations with several metabolism-related parameters. Plasma MaR1 concentrations were analyzed in 96 subjects with normal glucose tolerant (NC, n = 43), type 2 diabetes (T2DM, n = 40), or diabetic foot ulcer (DFU, n = 13). The intravenous glucose tolerance test (IVGTT) and biochemical parameters were measured in all participants. Plasma MaR1 concentrations were significant decreased in type 2 diabetes patient with or without DFU compared with NC (both P < 0.001) and were lowest in DFU patients among these 3 groups. (DFU vs. T2DM, P < 0.05). Plasma MaR1 concentrations were negatively correlated with BMI, waist circumference (Wc), waist hip ratio (WHR), systolic blood pressure (SBP), diastolic blood pressure (DBP), LDL-c, FPG, 2hPG, HbA1c, and homeostasis model assessment for insulin resistance (HOMA-IR) (all P < 0.05) and were positively correlated with HDL-c, acute insulin response (AIR), area under the curve of the first-phase (0-10 min) insulin secretion (AUC), and homeostasis model assessment for beta-cell function (HOMA-β) (all P < 0.05). After adjusting for age and sex, Wc, WHR...Continue Reading

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Mentioned in this Paper

Insulin Resistance
Glucose
Diabetic Foot
Analysis
Waist-Height Ratio
Glycosylated hemoglobin A
7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid
Plasma
Intravenous Glucose Tolerance Test
High Density Lipoprotein Cholesterol

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