Decreased plasminogen activator inhibitor-1 levels in coronary artery aneurysmatic patients

Journal of Thrombosis and Thrombolysis
Ertugrul ErcanMustafa Akin

Abstract

Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of arterial aneurysms through increased proteolysis of extracellular matrix proteins. Increased proteolysis due to elevated matrix degrading enzyme activity in the arterial wall may act as a susceptibility factor for the development of coronary aneurysms. Plasmin strongly stimulates pro-MMP enzyme conversion to the active form. Plasmin hyperactivity due to decreased plasminogen activator inhibitor-1 (PAI-1) may cause MMP over activity and coronary aneurysms. The aim of this study was to investigate the association between PAI-1 and presence of coronary aneurysms. Twenty-three patients with aneurysmal coronary artery disease and stable angina were enrolled into study (Group 1). Twenty-two patients without coronary aneurysm were selected as a control group (Group 2). PAI-1 was measured in peripheral venous blood. The plasma PAI-1 level was lower in the coronary artery aneurysmatic patients compared to the control group (8.41 +/- 4.28 vs. 13.32 +/- 10.05 ng/ml, p = 0.037). Serum C-reactive protein (CRP) values were not significantly different between groups (3.83 +/- 1.08 vs. 4.01 +/- 1.35 mg/l, p >0.05). Increased matrix degrading enzyme activity can cause ...Continue Reading

Citations

Aug 19, 2011·Journal of Thrombosis and Thrombolysis·Yuksel CicekAhmet Temiz
Aug 17, 2010·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Toshimitsu SatoKimihiro Komori
Oct 10, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Masayoshi KobayashiKimihiro Komori

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