Decreased platelet 5-hydroxytryptamin (5-HT) levels: a response to antidepressants

Journal of Affective Disorders
Xia LiZeping Xiao

Abstract

Platelet 5-hydroxytryptamin (serotonin, 5-HT) has been examined for its use as a peripheral biomarker for depression or other mental disorders; however, it remains unclear whether blood 5-HT levels can reflect the brain's levels of serotonin. Platelet 5-HT levels in 45 drug-naïve, 32 citalopram-treated patients with major depression and 32 healthy control were assayed, Hamilton Depression scale (HAMD) and Hamilton Anxiety Scale (HAMA) were assessed. We then measured 5-HT in platelet, in platelet-poor plasma and in the nuclei of brain tissues obtained from chronic unpredictable mild stress (CUMS) rats with or without citalopram treatment, and from the controls rats that were treated with vehicle. Toward this end, we analyzed whether correlations exist between platelet and brain. No differences were observed among drug-naïve patients, citalopram-treated patients and health control according to gender and age (p>0.05). Drug-naïve depressed patients had highest scores in HAMD and HAMA among the three groups (F=223.3, p<0.01; F=70.7, p<0.01, respectively) Citalopram-treated patients had significantly lower platelet 5-HT levels,compared to control subjects (Mean 58.1±36.8ng/10(9) versus 558.0±199.4ng/10(9), p<0.01) and compared to dr...Continue Reading

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Citations

Jul 20, 2019·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Huawei LiDianliang Zhang
Apr 3, 2019·Experimental and Therapeutic Medicine·Zheng GuYaqiong Han
Jul 17, 2018·Clinical Hemorheology and Microcirculation·Okan ArihanNeslihan Dikmenoglu Falkmarken
Mar 5, 2019·Journal of Affective Disorders·Amanda HolckDaniel Lindqvist
Apr 8, 2021·Biological Trace Element Research·Qiqi CaoZilong Sun

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