Abstract
Hypertriglyceridemia (HTG) is associated with insulin resistance, increased cholesteryl ester transfer (CET), and low HDL cholesterol. Phospholipid transfer protein (PLTP) may be involved in these relationships. Associations between CET, lipids, insulin resistance, CETP and PLTP activities, and PLTP mass were investigated in 18 HTG patients and 20 controls. Effects of 6 weeks of bezafibrate treatment were studied in HTG patients. HTG patients had higher serum triglycerides, insulin resistance, free fatty acid (FFA), and CET, lower levels of HDL cholesterol (-44%) and PLTP mass (-54%), and higher CETP (+20%) and PLTP activity (+48%) than controls. Bezafibrate reduced triglycerides, CET (-37%), insulin resistance (-53%), FFA (-48%), CETP activity (-12%), PLTP activity (-8%), and increased HDL cholesterol (+27%), whereas PLTP mass remained unchanged. Regression analysis showed a positive contribution of PLTP mass (P = 0.001) but not of PLTP activity to HDL cholesterol, whereas insulin resistance positively contributed to PLTP activity (P < 0.01). Bezafibrate-induced change in CET and HDL cholesterol correlated with changes in CETP activity and FFAs, but not with change in PLTP activity. Bezafibrate-induced change in PLTP activity ...Continue Reading
References
Dec 1, 1991·The Journal of Clinical Investigation·C J MannB E Bihain
Oct 1, 1991·Atherosclerosis·H SpeijerA van Tol
Aug 1, 1990·Diabetes Care·I R JonesK G Alberti
Jan 1, 1990·Atherosclerosis·K M ChannonP N Durrington
Jul 1, 1985·Diabetologia·D R MatthewsR C Turner
Nov 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·T MurakamiG Franceschini
Nov 1, 1995·Journal of Internal Medicine·J KahriM R Taskinen
Sep 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·L LagrostP Gambert
Nov 1, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·W H SutherlandH C Tillman
May 1, 1994·Atherosclerosis·H JansenJ C Birkenhäger
Mar 1, 1994·European Journal of Clinical Investigation·R P DullaartA Van Tol
Apr 1, 1994·Atherosclerosis·Y HommaH Nakamura
Jun 1, 1996·Arteriosclerosis, Thrombosis, and Vascular Biology·M GuérinM J Chapman
Jun 11, 1996·Biochimica Et Biophysica Acta·A von EckardsteinG Assmann
Apr 1, 1996·Current Opinion in Lipidology·P J Barter, K A Rye
Nov 5, 1997·The American Journal of Cardiology·J L ZambranaF Pérez-Jiménez
Apr 4, 1998·The American Journal of Cardiology·M A AustinK L Edwards
Apr 4, 1998·The American Journal of Cardiology·S M Grundy
Jun 17, 1998·Journal of Internal Medicine·J M MostazaS M Grundy
Sep 3, 1998·Diabetologia·S C RiemensR P Dullaart
Nov 10, 1998·Circulation·B StaelsJ C Fruchart
Nov 13, 1998·Current Opinion in Lipidology·M NavabA M Fogelman
Feb 12, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·C DesrumauxL Lagrost
Mar 17, 1999·The Journal of Clinical Investigation·X C JiangA R Tall
Jul 9, 1999·Biochimica Et Biophysica Acta·G WolfbauerJ F Oram
Apr 15, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·R van HaperenR de Crom
Aug 5, 2000·Atherosclerosis·J HuuskonenM Jauhiainen
May 9, 2001·The Journal of Biological Chemistry·M BoulyG Luc
Jul 4, 2001·Nature Medicine·X C JiangA R Tall
Jul 27, 2001·Diabetes·A Y Tu, J J Albers
Feb 21, 2002·The Journal of Biological Chemistry·Minna KärkkäinenChristian Ehnholm
Mar 14, 2002·Current Opinion in Lipidology·Arie van Tol
Oct 10, 2002·The Journal of Biological Chemistry·Rien van HaperenRini de Crom
Oct 29, 2002·Diabetes·Helen M ColhounArie Van Tol
Oct 29, 2002·Journal of Lipid Research·Jessica LieArie van Tol
Mar 4, 2003·Molecular and Cellular Biology·Bryan A LaffittePeter Tontonoz
Citations
Jan 24, 2006·Diabetologia·K Al MajaliD J Betteridge
May 29, 2004·Current Opinion in Lipidology·John J Albers, Marian C Cheung
May 15, 2007·Current Opinion in Lipidology·Geesje M Dallinga-ThieArie van Tol
Nov 26, 2009·Lipids in Health and Disease·Eliete J B BighettiHelena C F Oliveira
Oct 27, 2010·Lipids in Health and Disease·Tetsuro MiyazakiHiroyuki Daida
Jan 2, 2008·European Journal of Endocrinology·Robin P F DullaartArie van Tol
Apr 22, 2014·The Journal of Nutritional Biochemistry·Helena F RaposoHelena C F Oliveira
Aug 25, 2010·Current Medical Research and Opinion·Ioannis K KaralisJ Wouter Jukema
Sep 20, 2007·Clinical Endocrinology·Robin P F DullaartArie van Tol
Aug 30, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·J P H Wilding
Dec 23, 2015·International Journal of Molecular Sciences·Ian James Martins
Mar 1, 2007·Journal of Clinical Lipidology·Ngoc-Anh Le, Mary F Walter
Jun 8, 2007·Atherosclerosis·Wilfried SchgoerBernhard Foeger
May 26, 2007·Clinical Endocrinology·Robin P F DullaartArie van Tol
Feb 8, 2005·Atherosclerosis·O Stein, Y Stein
Apr 27, 2010·Biochemical Pharmacology·Rudel A SaundersKhew-Voon Chin
Dec 4, 2010·Biochimica Et Biophysica Acta·Noemí RotllanJoan Carles Escolà-Gil
Aug 18, 2009·Atherosclerosis·Vasilis TsimihodimosAlexandros D Tselepis
Apr 29, 2006·Diabetes·Geesje M Dallinga-ThieEric J G Sijbrands
Aug 20, 2008·Journal of Lipid Research·Hannelore SamynRini de Crom
Sep 3, 2004·Journal of Lipid Research·Minna T JänisChristian Ehnholm
Mar 3, 2004·Journal of Lipid Research·D R WitteH M Colhoun
May 26, 2007·Journal of Lipid Research·Caroline C van der HoogtPatrick C N Rensen
Sep 21, 2017·Nutrients·Yu QinJun-Dong Zhu
May 17, 2006·Clinical Science·Gerald F WattsP Hugh R Barrett