Decreased PLTP mass but elevated PLTP activity linked to insulin resistance in HTG: effects of bezafibrate therapy.

Journal of Lipid Research
Iris J A M JonkersArie van Tol

Abstract

Hypertriglyceridemia (HTG) is associated with insulin resistance, increased cholesteryl ester transfer (CET), and low HDL cholesterol. Phospholipid transfer protein (PLTP) may be involved in these relationships. Associations between CET, lipids, insulin resistance, CETP and PLTP activities, and PLTP mass were investigated in 18 HTG patients and 20 controls. Effects of 6 weeks of bezafibrate treatment were studied in HTG patients. HTG patients had higher serum triglycerides, insulin resistance, free fatty acid (FFA), and CET, lower levels of HDL cholesterol (-44%) and PLTP mass (-54%), and higher CETP (+20%) and PLTP activity (+48%) than controls. Bezafibrate reduced triglycerides, CET (-37%), insulin resistance (-53%), FFA (-48%), CETP activity (-12%), PLTP activity (-8%), and increased HDL cholesterol (+27%), whereas PLTP mass remained unchanged. Regression analysis showed a positive contribution of PLTP mass (P = 0.001) but not of PLTP activity to HDL cholesterol, whereas insulin resistance positively contributed to PLTP activity (P < 0.01). Bezafibrate-induced change in CET and HDL cholesterol correlated with changes in CETP activity and FFAs, but not with change in PLTP activity. Bezafibrate-induced change in PLTP activity ...Continue Reading

References

Dec 1, 1991·The Journal of Clinical Investigation·C J MannB E Bihain
Nov 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·T MurakamiG Franceschini
Nov 1, 1995·Journal of Internal Medicine·J KahriM R Taskinen
Sep 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·L LagrostP Gambert
Nov 1, 1994·Clinica Chimica Acta; International Journal of Clinical Chemistry·W H SutherlandH C Tillman
Jun 11, 1996·Biochimica Et Biophysica Acta·A von EckardsteinG Assmann
Apr 1, 1996·Current Opinion in Lipidology·P J Barter, K A Rye
Apr 4, 1998·The American Journal of Cardiology·M A AustinK L Edwards
Apr 4, 1998·The American Journal of Cardiology·S M Grundy
Nov 10, 1998·Circulation·B StaelsJ C Fruchart
Nov 13, 1998·Current Opinion in Lipidology·M NavabA M Fogelman
Apr 15, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·R van HaperenR de Crom
Feb 21, 2002·The Journal of Biological Chemistry·Minna KärkkäinenChristian Ehnholm
Mar 14, 2002·Current Opinion in Lipidology·Arie van Tol
Oct 10, 2002·The Journal of Biological Chemistry·Rien van HaperenRini de Crom
Oct 29, 2002·Journal of Lipid Research·Jessica LieArie van Tol

❮ Previous
Next ❯

Citations

May 29, 2004·Current Opinion in Lipidology·John J Albers, Marian C Cheung
Apr 22, 2014·The Journal of Nutritional Biochemistry·Helena F RaposoHelena C F Oliveira
Aug 30, 2007·Diabetic Medicine : a Journal of the British Diabetic Association·J P H Wilding
Dec 23, 2015·International Journal of Molecular Sciences·Ian James Martins
Mar 1, 2007·Journal of Clinical Lipidology·Ngoc-Anh Le, Mary F Walter
Jun 8, 2007·Atherosclerosis·Wilfried SchgoerBernhard Foeger
May 26, 2007·Clinical Endocrinology·Robin P F DullaartArie van Tol
Feb 8, 2005·Atherosclerosis·O Stein, Y Stein
Apr 27, 2010·Biochemical Pharmacology·Rudel A SaundersKhew-Voon Chin
Dec 4, 2010·Biochimica Et Biophysica Acta·Noemí RotllanJoan Carles Escolà-Gil
Sep 3, 2004·Journal of Lipid Research·Minna T JänisChristian Ehnholm
May 26, 2007·Journal of Lipid Research·Caroline C van der HoogtPatrick C N Rensen

❮ Previous
Next ❯

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.