Decreased prostaglandin E2 production by inflammatory cytokine and lower expression of EP2 receptor result in increased collagen synthesis in keloid fibroblasts

The Journal of Investigative Dermatology
Toshihiko HayashiYuhei Yamamoto

Abstract

We investigated the metabolism of arachidonic acid in normal skin-derived fibroblasts (NF) as well as in keloid-derived fibroblasts (KF) in response to macrophage migration inhibitory factor (MIF), a pluripotent cytokine. We found that MIF enhanced cyclooxygenase-2 activity in NF more than in KF. Consistent with this finding, prostaglandin E(2) (PGE(2)), an antifibrogenic molecule, was more significantly increased in NF than in KF by MIF treatment. As regarding E prostanoid receptor 2, the level of expression was significantly lower in KF than in NF. On the other hand, Forskolin, a direct activator of adenylcyclase, decreased collagen synthesis in both NF and KF, which indicates that cAMP plays an important role in regulating collagen synthesis. As PGE(2) induces cAMP production, it is conceivable that increased collagen synthesis in KF might be owing to decreased PGE(2) and cAMP production. These findings may aid in the development of a therapeutic strategy for the regulation of collagen synthesis in keloid fibroblasts.

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Citations

May 3, 2013·Lipids in Health and Disease·Chenyu Huang, Rei Ogawa
Jan 25, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Vlad C SandulachePatricia A Hebda
Nov 22, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Tadashi NomuraShinya Tahara
Feb 5, 2010·The British Journal of Dermatology·C T OngT T Phan
Jul 31, 2010·Mediators of Inflammation·Wen-Hsiang SuPeng-Hui Wang
Jul 25, 2008·The Journal of Craniofacial Surgery·Brian BermanIsaac S Jones
Nov 10, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Miguel Perez-AsoBruce N Cronstein
Mar 13, 2014·Experimental Dermatology·Naoki MuraoAkihiko Oyama
May 26, 2017·Anais Brasileiros De Dermatologia·Kazuhiro ToriiMakoto Usami
Nov 11, 2019·International Journal of Molecular Sciences·Joong Hyun Shim

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