Abstract
The plasma levels of protein C were investigated in 54 type I diabetic patients without retinopathy and in 14 diabetic patients with diabetic retinopathy and compared with the findings in 35 sex- and age-matched healthy control subjects. In the total group of type I diabetic patients, protein C was significantly less than in the controls. The lowest levels of protein C were found in diabetic patients with the poorest metabolic control. Protein C levels showed a significant negative correlation with the blood glucose levels, but they were not correlated with hemoglobin A1c (HbA1c). Although patients with retinopathy showed the least decrease of the plasma level of protein C among the diabetic subjects, the ratio of protein C to factor II was significantly decreased compared with the control subjects. Because the levels of coagulation factor II were not reduced in diabetic patients, the reduction of protein C seems to be caused, not by reduced synthesis in the liver, but more likely by an increased clearance from the blood plasma. The decrease of protein C in the plasma of type I diabetic patients indicates an abnormal, probably hypercoagulable, hemostatic situation in this disorder.
Citations
Apr 1, 1993·Diabetes/metabolism Reviews·S A Amiel
Nov 1, 1993·Diabetologia·A Ceriello
Oct 1, 1993·Diabetologia·P KnöblM Müller
Jun 30, 1989·Clinica Chimica Acta; International Journal of Clinical Chemistry·H TakahashiA Shibata
Mar 22, 2001·Journal of Diabetes and Its Complications·M E Carr
Mar 27, 2012·The Journal of Biological Chemistry·Meilang XueChristopher J Jackson
Mar 23, 2011·Stroke Research and Treatment·Jennifer Ruth FosterDouglas D Fraser
Mar 14, 2013·BioMed Research International·K WhitmontC J Jackson
Nov 5, 2004·Journal of Perinatology : Official Journal of the California Perinatal Association·Shikha SarkarVictor C Herson
Jun 1, 1995·Acta Diabetologica·M VeglioP Cavallo-Perin
Sep 1, 1996·Acta Diabetologica·A MormileP Cavallo-Perin
Jul 14, 2009·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Patrick van DredenThomas Exner
Jun 7, 2007·Clinical Cardiology·Charalambos AntoniadesChristodoulos Stefanadis
Oct 1, 1988·Metabolism: Clinical and Experimental·S H SchneiderN B Ruderman
Sep 15, 1992·Thrombosis Research·F CarmassiG Mariani
Dec 1, 1988·Thrombosis Research·M SaitoT Matsuda
Jan 1, 1988·Diabetes Research and Clinical Practice·E Standl
Nov 1, 1989·British Journal of Haematology·G SchernthanerM M Müller
Jan 18, 2006·Diabetes Research and Clinical Practice·G V GillP English
Jul 11, 2008·Expert Opinion on Biological Therapy·Chris JacksonMeilang Xue
Nov 3, 2004·The Journal of Clinical Investigation·Greet Van den Berghe
Jun 1, 1997·The Journal of Dermatology·S AkimotoY Miyachi
Sep 1, 1993·Thrombosis Research·Y TakadaA Takada
Apr 8, 2014·Orvosi hetilap·Ibolya HegedűsGyörgy Ungváry
Apr 1, 2003·Endocrine Research·G F CarlMary H Jonah
Dec 21, 2004·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Cihangir EremMünir Telatar
Jan 17, 2019·Rheumatology·Meilang XueChristopher J Jackson