PMID: 9174244May 20, 1997Paper

Decreased receptivity of pathway connective tissue to sympathetic nerve ingrowth in the developing rat

Brain Research. Developmental Brain Research
J HiebertP G Smith

Abstract

Sympathetic axons can form atypical pathways to denervated orbital targets in neonatal rats but not in rats aged 30 or more days. The objective of this study was to determine if connective tissue pathways that carry sympathetic nerves lose their ability to sustain axonal sprouting during the early postnatal period. Regions of periorbital sheath known to contain large numbers of sympathetic axons that travel to distal orbital targets were excised from rats (sympathectomized 3 days previously) on postnatal days 6-7, 14-15, 30-31, and 48-49 and placed in anterior chambers of adult host rats. Tissues were removed 3, 6, or 10 days post-transplant and sympathetic ingrowth was analyzed by catecholamine histofluorescence in whole-mount or cryosectioned specimens. Connective tissue transplants from 6-15-day-old donors showed significant fiber ingrowth by 3 days in oculo, and innervation was maximal by 6 days. In contrast, sprouting into 30-49-day-old tissue was significantly slower, with most transplants lacking fibers at 3 days, and with small numbers of short fibers present at 6 days. We conclude that maturational changes occur in periorbital connective tissue pathways in the early postnatal period which make them less receptive to in...Continue Reading

References

May 1, 1975·Developmental Biology·P C Letourneau
Sep 8, 1992·The Journal of Comparative Neurology·D W Vaughan
Jan 1, 1991·Journal of Cell Science. Supplement·D Edgar
Nov 15, 1990·The Journal of Comparative Neurology·P G Smith, H Reddy
Sep 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J DiamondB Visheau
Oct 1, 1980·Journal of Neuroscience Methods·J C De la Torre
Jun 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S Korsching, H Thoenen
Dec 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D L Shelton, L F Reichardt
Jun 1, 1995·Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery·S J ChoiK Ueda
Nov 1, 1994·Journal of Neurobiology·A M Davies
Jan 1, 1993·Annual Review of Neuroscience·D J Anderson
Oct 1, 1995·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J Hiebert, P G Smith
Jan 1, 1989·The Western Journal of Medicine·V R Hentz

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