PMID: 15232892Jul 6, 2004Paper

Decreased red blood cells deformability in acute pancreatitis in the rat. Effect of tirilazad mesylate

Folia medica Cracoviensia
Bogdan ChmielLech Cierpka

Abstract

The ability of erythrocytes to deform is the key feature in maintain the microcirculation. Both acute pancreatitis and decrease in deformability of erythrocytes are associated with increase in lipid peroxidation as a result of excess production of free radicals. Hence the aim of this study was to investigate the red blood cell (RBC) deformability and lipid peroxidation product content within erythrocytes in acute pancreatitis in rats. Rats with cerulein induced acute edematous pancreatitis (CR), pancreatitis induced by cerulein and water immersion stress (CR + WIS) and closed duodenal loop pancreatitis (CDL) treated by tirilazad mesylate were sacrificed in 9 th hour of the experiment. Deformability of erythrocytes has been investigated by means of shear stress diffractometry and expressed as elongation index (EI). Histological scoring and serum amylase were used as parameters of acute pancreatitis. Lipid peroxidation products have been assayed in RBC as a malonyldialdehyde. 1. There were no changes in EI of RBC during CR. 2. EI of RBC were impaired at low shear stresses (up to 3.0 Pa) but not in higher shear stresses in CR + WIS. 3. CDL are associated with decreases of elongation indexes in all shear stresses. 4. Tirilazad mesy...Continue Reading

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