Decreased regional activity and network homogeneity of the fronto-limbic network at rest in drug-naive major depressive disorder

The Australian and New Zealand Journal of Psychiatry
Wenbin GuoJingping Zhao

Abstract

The fronto-limbic network is implicated in the neurobiology of major depressive disorder. However, no studies are designed to assess directly the abnormalities of regional activity and network homogeneity of this network in major depressive disorder. A total of 44 drug-naive major depressive disorder patients and 44 healthy controls participated in the study, and resting-state functional magnetic resonance imaging data were obtained. The fractional amplitude of low-frequency fluctuations and network homogeneity methods were employed to analyze the data. Compared with the controls, the patients exhibited reduced fractional amplitude of low-frequency fluctuations in the right middle frontal gyrus (orbital part) and decreased network homogeneity in the left middle frontal gyrus. There was no correlation between abnormal fractional amplitude of low-frequency fluctuations/network homogeneity and clinical variables. Our findings suggest that decreased regional activity and network homogeneity in the frontal cortex may be the key impairment of the fronto-limbic network in major depressive disorder, and thus highlight the importance of the fronto-limbic network in the neurobiology of major depressive disorder.

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Citations

Feb 9, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ming ZhouXiaoqi Huang
Jun 14, 2017·The Australian and New Zealand Journal of Psychiatry·Wenbin GuoJingping Zhao
Nov 27, 2015·The Australian and New Zealand Journal of Psychiatry·Wenbin GuoJingping Zhao
Apr 29, 2018·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Xilong CuiWenbin Guo
Nov 23, 2017·Human Brain Mapping·Jeffrey N BrowndykeUNKNOWN Duke Neurologic Outcomes Research Group (NORG)
Feb 26, 2016·Journal of Perinatology : Official Journal of the California Perinatal Association·A SehgalS Menahem
Jul 25, 2017·Frontiers in Neuroscience·Linlin LiuQuan Zhang
Mar 9, 2020·NeuroImage. Clinical·Wenjun HongChetwyn C H Chan

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Software Mentioned

REST
fALFF
MATLAB
SPM8
Data Processing Assistant for Resting - State fMRI ( DPARSF )

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