Decreased Regional Homogeneity in Patients With Acute Mild Traumatic Brain Injury: A Resting-State fMRI Study

The Journal of Nervous and Mental Disease
Jie ZhanHong-Han Gong

Abstract

Mild traumatic brain injury (mTBI) is characterized by structural disconnection and large-scale neural network dysfunction in the resting state. However, little is known concerning the intrinsic changes in local spontaneous brain activity in patients with mTBI. The aim of the current study was to assess regional synchronization in acute mTBI patients. Fifteen acute mTBI patients and 15 sex-, age-, and education-matched healthy controls (HCs) were studied. We used the regional homogeneity (ReHo) method to map local connectivity across the whole brain and performed a two-sample t-test between the two groups. Compared with HCs, patients with acute mTBI showed significantly decreased ReHo in the left insula, left precentral/postcentral gyrus, and left supramarginal gyrus (p < 0.05, AlphaSim corrected). The ReHo index of the left insula showed a positive correlation with the Mini-Mental State Examination (MMSE) scores across all acute mTBI patients (p < 0.05, uncorrected). The ReHo method may provide an objective biomarker for evaluating the functional abnormity of mTBI in the acute setting.

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Citations

Jan 29, 2016·Brain Imaging and Behavior·Timothy B MeierAndrew R Mayer
Apr 12, 2016·Frontiers in Human Neuroscience·Patrizia Dall'AcquaJürgen Hänggi
Jan 13, 2017·PloS One·Hongbo Chen, Shaofeng Mo
Jun 28, 2020·Journal of Magnetic Resonance Imaging : JMRI·David D StephensonAndrew R Mayer
Aug 1, 2020·Frontiers in Psychology·Maria Calvillo, Andrei Irimia
Jan 8, 2021·Acta Neuropathologica Communications·Xuan Vinh To, Fatima A Nasrallah
Sep 18, 2021·Journal of the Academy of Consultation-Liaison Psychiatry·Sahar JahedMatthew E Peters

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