PMID: 7545811Jun 1, 1995Paper

Decreased renal haemodynamic response to inhibition of nitric oxide synthase in subtotally nephrectomized rats

Pflügers Archiv : European journal of physiology
J WagnerE Ritz

Abstract

To assess the renal haemodynamic response to manipulations of the nitric oxide (NO) system, we examined subtotally nephrectomized (SNX) rats and control rats (CON) 28 days after their operation. Bolus infusions of the NO synthase inhibitor NG-nitro-L-arginine (L-NA) were given intravenously at doses of 2 mg/kg and 10 mg/kg. Blood pressure was measured intra-arterially, glomerular filtration rate was measured by inulin clearance and fractional changes in renal blood flow (RBF) were determined by a Doppler flow probe. Both doses of L-NA caused a similar and dose-dependent increase in mean blood pressure in both SNX and CON rats. In contrast, the decrease in RBF and the increase in the renovascular resistance index (RVRI) was less in SNX rats as compared to CON rats (RBF = -70.1 +/- 2.2% of baseline vs -52.7 +/- 5.2%, P < 0.01; RVRI = +177 +/- 9% of baseline vs +243 +/- 24%, P < 0.05). These changes were not affected by autonomic blockade (hexamethonium), or by blockade of the angiotensin II receptor (Losartan). The exogenous NO donor sodium nitroprusside (0.5 and 1.5 micrograms.kg-1.min-1) lowered mean blood pressure to a similar degree in SNX and CON rats; in contrast, RVRI decreased less in SNX rats (86.9 +/- 9.2% of baseline) ...Continue Reading

References

Jan 1, 1992·Journal of Cardiovascular Pharmacology·P VallanceS Moncada
Dec 1, 1991·The American Journal of Physiology·J G WongD E Johnson
Jun 1, 1991·Journal of the American Society of Nephrology : JASN·A J KingB M Brenner
Dec 1, 1990·Journal of the American Society of Nephrology : JASN·C BaylisK Engels
May 1, 1990·Hypertension·S M GardinerS Moncada
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D D ReesS Moncada
Mar 1, 1989·Kidney International·L D DworkinM Parker
Nov 1, 1988·Renal Physiology and Biochemistry·P J HorstT Unger
May 1, 1993·Journal of Hypertension·A U FerrariG Mancia

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