PMID: 2500404Jan 1, 1989Paper

Decreased resistance to Listeria monocytogenes in mice following vanadate exposure: effects upon the function of macrophages

International Journal of Immunopharmacology
M D CohenC I Wei

Abstract

We have previously demonstrated that ammonium metavanadate has a broad immunomodulating effect in mice after subchronic exposure. Because host resistance to pathogenic Listeria monocytogenes and in vitro phagocytic activity of harvested peritoneal macrophages (PEM) were strongly affected by vanadate treatment, we investigated the effect of vanadate on the functional role of resident PEM in active listeriosis in the mouse. Vanadium treatment results in altered patterns of clearance of the organism from the peritoneal cavity, liver and spleen. The total in vitro phagocytic uptake of Listeria by PEM was consistently decreased as a function of infection period. Similarly, intracellular killing of Listeria was decreased although the PEM from the vanadate-treated and control mice were more bacteriostatic than bactericidal. Population distributions of Listeria within infected PEM were not affected by host pretreatment with vanadate. Vanadate exposure interferes with both the uptake and ultimate intraphagolysosomal killing of Listeria. These results were expected in light of our previous studies of the effects of vanadate on PEM superoxide production, and hexose monophosphate shunt and glutathione redox cycle activity. The results prov...Continue Reading

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Citations

Jun 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H Zaporowska, W Wasilewski
Jan 1, 1992·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·H Zaporowska, W Wasilewski
May 8, 1999·Veterinary Immunology and Immunopathology·M A QureshiC L Heggen
May 1, 1991·Journal of Toxicology and Environmental Health·K Vaddi, C I Wei
Aug 29, 1997·Journal of Toxicology and Environmental Health·M D CohenJ T Zelikoff
Oct 30, 2008·Journal of Immunotoxicology·Mitchell D CohenDebbie C Crans
Dec 13, 2006·Methods : a Companion to Methods in Enzymology·Mitchell D Cohen
Dec 6, 1995·Molecular and Cellular Biochemistry·F G Hamel, W C Duckworth
Oct 30, 2008·Journal of Immunotoxicology·Mitchell D CohenDebbie C Crans
Feb 27, 2001·Toxicology and Applied Pharmacology·M D CohenR B Schlesinger
Sep 4, 2008·Journal of Pharmacological and Toxicological Methods·Nils-Gunnar IlbäckGöran Friman

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