Decreased Resting-State Connectivity between Neurocognitive Networks in Treatment Resistant Depression

Frontiers in Psychiatry
Bart de KwaastenietDamiaan Denys

Abstract

Approximately one-third of patients with major depressive disorder (MDD) do not achieve remission after various treatment options and develop treatment resistant depression (TRD). So far, little is known about the pathophysiology of TRD. Studies in MDD patients showed aberrant functional connectivity (FC) of three "core" neurocognitive networks: the salience network (SN), cognitive control network (CCN), and default mode network (DMN). We used a cross-sectional design and performed resting-state FC MRI to assess connectivity of the SN, CCN, and both anterior and posterior DMN in 17 severe TRD, 18 non-TRD, and 18 healthy control (HC) subjects. Relative to both non-TRD and HC subjects, TRD patients showed decreased FC between the dorsolateral prefrontal cortex and angular gyrus, which suggests reduced FC between the CCN and DMN, and reduced FC between the medial prefrontal cortex and precuneus/cuneus, which suggests reduced FC between the anterior and posterior DMN. No significant differences in SN FC were observed. Our results suggest that TRD is characterized by a disturbance in neurocognitive networks relative to non-TRD and HC.

References

Aug 29, 1996·Nature·S GeyerP E Roland
Jan 9, 1998·Progress in Neuro-psychopharmacology & Biological Psychiatry·M HornigJ D Amsterdam
May 8, 2002·Nature Reviews. Neuroscience·Maurizio Corbetta, Gordon L Shulman
Sep 3, 2002·The British Journal of Psychiatry : the Journal of Mental Science·T Bedirhan Ustün, Ron C Kessler
Aug 30, 2003·Biological Psychiatry·Mary L PhillipsRichard Lane
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON
Jan 27, 2004·NeuroImage·Joseph A MaldjianJonathan H Burdette
Mar 8, 2005·Neuron·Helen S MaybergSidney H Kennedy
Apr 28, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amit AnandMark J Lowe
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michael D FoxMarcus E Raichle
Oct 13, 2006·Psychiatry Research·Paul B FitzgeraldZafiris J Daskalakis
Mar 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·William W SeeleyMichael D Greicius
Apr 21, 2007·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Marcelo T Berlim, Gustavo Turecki
Aug 21, 2007·Nature Reviews. Neuroscience·Michael D Fox, Marcus E Raichle
Nov 8, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chi-Hua ChenEd Bullmore
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Devarajan SridharanVinod Menon
Feb 5, 2009·The Journal of Clinical Psychiatry·Abebaw FekaduAnthony J Cleare
Aug 1, 2009·Trends in Cognitive Sciences·Tania SingerKerstin Preuschoff
Nov 6, 2009·Journal of Neurophysiology·Koene R A Van DijkRandy L Buckner
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Bharat B BiswalMichael P Milham
May 18, 2010·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Martijn P van den Heuvel, Hilleke E Hulshoff Pol
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Yvette I ShelineMark A Mintun
Oct 14, 2010·Frontiers in Systems Neuroscience·Ilya M VeerSerge A R B Rombouts
Mar 3, 2011·The American Journal of Psychiatry·Su LuiQiyong Gong
Mar 26, 2011·Journal of Affective Disorders·Henricus G RuhéAart H Schene
Jun 23, 2011·Journal of Psychiatry & Neuroscience : JPN·Lena Palaniyappan, Peter F Liddle
Aug 19, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Marie-Laure Paillère MartinotEric Artiges
Jan 1, 2013·Biological Psychiatry·Baojuan LiDewen Hu
Feb 8, 2013·JAMA Psychiatry·Jonathan PosnerBradley S Peterson
Oct 1, 1997·Journal of Cognitive Neuroscience·G L ShulmanS E Petersen

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Citations

Nov 17, 2015·Journal of Affective Disorders·Marc S LenerJames W Murrough
Apr 6, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yong-Ku Kim, Kyoung-Sae Na
Oct 27, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Rodney J AndersonPaul B Fitzgerald
Mar 21, 2017·Radiology·Zhiyun JiaQiyong Gong
May 21, 2017·Scientific Reports·David RosenbaumAnn-Christine Ehlis

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Software Mentioned

SPM
REST
WFU
Pickatlas
Statistical Parametric Mapping ( SPM8

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