Decreased reward sensitivity in rats from the Fischer344 strain compared to Wistar rats is paralleled by differences in endocannabinoid signaling.

PloS One
Theresa BrandMiriam Schneider

Abstract

The aim of the present study was to examine if differences in the endocannabinoid (ECB) system might be linked to strain specific variations in reward-related behavior in Fischer344 (Fischer) and Wistar rats. Two rat strains, the Fischer and the Wistar strain, were tested for different aspects of reward sensitivity for a palatable food reward (sweetened condensed milk, SCM) in a limited-access intake test, a progressive ratio (PR) schedule and the pleasure-attenuated startle (PAS) paradigm. Additionally, basic differences in the ECB system and cannabinoid pharmacology were examined in both rat strains. Fischer rats were found to express lower reward sensitivity towards SCM compared to Wistar rats. These differences were observed for consummatory, motivational and hedonic aspects of the palatable food reward. Western blot analysis for the CB1 receptor and the ECB degrading enzyme fatty acid amide hydrolase (FAAH) revealed a lower expression of both proteins in the hippocampus (HPC) of Fischer rats compared to the Wistar strain. Furthermore, increased cannabinoid-stimulated extracellular-regulated kinase (ERK) phosphorylation was detected in Wistar rats compared to the Fischer strain, indicating alterations in ECB signaling. Thes...Continue Reading

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Citations

May 15, 2013·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Peggy SchneiderMiriam Schneider
Apr 11, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chris M FriemelMiriam Schneider
Jun 27, 2013·The Journal of Pharmacology and Experimental Therapeutics·Lisa K BrentsWilliam E Fantegrossi
Sep 1, 2014·Neuroscience and Biobehavioral Reviews·C D'AddarioM Maccarrone
Jun 17, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Antonia ManducaViviana Trezza
Jun 17, 2018·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Máté DurstZsuzsanna E Tóth
Jun 23, 2018·Brain Structure & Function·Michael Ohene-NyakoT Celeste Napier

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Methods Mentioned

BETA
Dissection
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electrophoresis

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MCID Core

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