PMID: 7007680Mar 6, 1981Paper

Decreased secondary hyperparathyroidism in diabetic patients receiving hemodialysis

JAMA : the Journal of the American Medical Association
F VincentiO Salvatierra

Abstract

Biochemical and bone scintigraphic studies were performed in nondiabetic and diabetic patients receiving hemodialysis at the time of kidney transplantation to assess the degree of secondary hyperparathyroidism. Despite lower serum calcium concentrations, diabetic patients had significantly lower parathyroid hormone (PTH) levels than nondiabetic patients. In addition, diabetic patients had lower graded total-skeletal scintigraphic scores than nondiabetic patients. The PTH levels showed positive correlations with bone scan scores and with alkaline phosphatase in nondiabetic patients but not in diabetic patients. Avascular necrosis occurred in 17% of nondiabetic patients and in only 2% of diabetic patients. Patients with avascular necrosis had significantly higher PTH levels than patients without avascular necrosis. Diabetes mellitus seems to confer a protective effect from the skeletal manifestations of secondary hyperparathyroidism, including avascular necrosis.

Citations

May 1, 1988·Calcified Tissue International·J AubiaJ Masramon
Mar 1, 1991·Aging : Clinical and Experimental Research·K AsaiF Kuzuya
Aug 2, 2003·The New England Journal of Medicine·Ming TengRavi Thadhani
Jun 1, 1990·Kidney International·T SugimotoE Slatopolsky
Apr 1, 1984·Kidney International·F VincentiO Salvatierra
Jan 1, 1988·The American Journal of Medicine·W J JohnsonP C Kao
Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D L AndressD J Sherrard
Apr 9, 2010·Seminars in Dialysis·Radica Z Alicic, Katherine R Tuttle

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