Decreased sensitivity of the automatic white precursor cell channel (WPC) for blast flagging in patients with leukopenia

Clinical Biochemistry
Nuri LeeDong Soon Lee

Abstract

The advantage of Sysmex XN system is its performance of an automatic reflex test in white cell precursor (WPC) channel, which gives an accurate differential count. We performed a real-time evaluation of the automatic differential count according to WBC number with Sysmex XN series and demonstrated a significant differential impact on blast distinction depending on the number of WBC. We categorized the 49,699 specimen according to WBC number and compared the results of blast flagging in the white cell differential (WDF) channel and WPC channel on the basis of the results of manual differential count. Additionally, clinical impact of missed blasts after running WPC reflex test was analyzed. For patients with WBC under 1.5×10(9)/L, blast flagging for WPC channel showed markedly decreased sensitivity (56%) compared to that of WDF mode (100%). Most of the patients with missed blasts in WPC mode were under chemotherapy or hematopoietic stem cell transplantation. The specificity and efficiency for WPC channel were much higher than that of WDF mode in all range of WBC. Considering the additional reagent cost required for the WPC channel, WPC reflex test is not suitable for patients with leukopenia if it is operated alone. Instead, manu...Continue Reading

References

Aug 2, 2012·Journal of Clinical Pathology·Carol BriggsSamuel J Machin
Apr 19, 2013·American Journal of Clinical Pathology·Heidi EilertsenTor-Arne Hagve
Feb 15, 2014·World Journal of Clinical Cases·Federico GobbiZeno Bisoffi
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Jul 1, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Hanah KimIn Sook Sohn

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Citations

Oct 23, 2016·Clinical Biochemistry·Madelon NoordegraafJanneke Ruinemans-Koerts
Jun 5, 2019·International Journal of Laboratory Hematology·Jessica PetroneJohn L Frater
Jul 9, 2020·International Journal of Laboratory Hematology·Jesper SejrupJulie Smith
Oct 2, 2020·International Journal of Laboratory Hematology·Siska BlommeChristine Van Laer

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