PMID: 3214562Oct 1, 1988Paper

Decreased serum phosphate in essential hypertension. Related to increased sympathetic tone

American Journal of Hypertension
S E KjeldsenK Gautvik

Abstract

Forty-year old men with untreated mild essential hypertension (n = 35) had decreased serum phosphate (P less than 0.001) concomitant with elevated resting plasma epinephrine (P less than 0.05) and heart rate (P less than 0.001) compared with age-matched, normotensive control men (n = 44). Blood pressure correlated negatively with serum phosphate (P less than 0.001) and positively with plasma epinephrine (P less than 0.01) and heart rate (P less than 0.01). Serum phosphate was significantly lowered during infusion of epinephrine, increasing arterial plasma epinephrine within the lower pathophysiological range corresponding to arousal reactions. Serum concentrations of immunoreactive parathyroid hormone were unchanged. Thus, hypophosphatemia in patients with mild essential hypertension appears to be inversely related to sympathetic adrenal tone and may be caused by increased plasma epinephrine within pathophysiologic arterial concentrations.

Citations

Jun 1, 1990·Scandinavian Journal of Clinical and Laboratory Investigation·S E KjeldsenI K Eide
Jan 9, 2009·The Journal of Clinical Hypertension·Helga GudmundsdottirIngrid Os
Jul 1, 2014·Nutrition & Diabetes·O A ObeidJ J Ayoub
May 28, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Gregory VyssoulisChristodoulos Stefanadis
Jan 1, 1993·Journal of Internal Medicine·I OsA Westheim
Oct 5, 2017·Archives of Endocrinology and Metabolism·Muhammed KizilgulErman Cakal
May 13, 2017·Acta Anaesthesiologica Scandinavica·E JunttilaT Ala-Kokko
Dec 23, 2008·Diabetes Research and Clinical Practice·Wan ParkSun Woo Kim

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