Aug 14, 1975

Decreased serum salicylate concentrations in children with rheumatic fever treated with antacid

The New England Journal of Medicine
G LevyL K Garrettson

Abstract

To determine if the common practice of giving antacids to patients on salicylate therapy has an effect on serum salicylate concentrations, we gave a widely used antacid, aluminum and magnesium hydroxide, and aspirin concomitantly to three children with rheumatic fever. Urinary pH increased appreciably, and serum salicylate concentrations decreased by 30 to 70 per cent. In five healthy adult volunteers concomitant administration of antacid had no effect on the bioavailability of aspirin. Pharmacokinetic analysis revealed that the antacid-induced decrease of serum salicylate concentrations was due to increased renal clearance of salicylate caused by the rise in urinalry pH.

  • References5
  • Citations21
  • References5
  • Citations21

Citations

Mentioned in this Paper

Kidney
Alhydrogel
Zorprin
Hydroxides
Antacids
Rheumatic Fever
Salicylic Acids
Hydrogen-Ion Concentration
Magnesium

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