Decreased serum semicarbazide sensitive aminooxidase (SSAO) activity in patients with major depression

Progress in Neuro-psychopharmacology & Biological Psychiatry
Veit RoessnerStefan Bleich

Abstract

Semicarbazide sensitive aminooxidase (SSAO) is known to interplay with monoamine oxidases (MAO) and several antidepressants. Taking into account the monoamine hypothesis concerning the pathophysiology of depression, the aim of the present pilot study was to evaluate serum SSAO activity in depressed patients. A total of 21 inpatients with major depression and 41 healthy controls were studied. Serum SSAO activity was determined by HPLC on days 1, 5 and 10 of inpatient treatment. At baseline without medication including antidepressants, highly depressed patients (MADRS score>or=30) had significantly decreased serum SSAO activity (mean 385+/-161 mU/l) when compared to healthy controls (mean 526+/-141 mU/l; p=0.003). This SSAO decrease was less pronounced at day 5 and day 10 under an antidepressive drug regime. Decreased serum SSAO activity was observed in patients with major depression, especially in those with high MADRS scores. The present results support the hypothesis of dysfunctional monoaminergic metabolism in the pathogenesis of depressive disorders. The disputable association between depression and monoamine metabolism requires further investigation, particularly with regard to SSAO activity and medication status.

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Citations

Aug 24, 2006·European Archives of Psychiatry and Clinical Neuroscience·Helge Frieling, Stefan Bleich
Aug 20, 2015·Critical Reviews in Clinical Laboratory Sciences·Roos PannecoeckMarijn M Speeckaert
Oct 2, 2012·Journal of the American Academy of Child and Adolescent Psychiatry·Catia ScassellatiMassimo Gennarelli
Jan 31, 2006·Behavioral and Brain Functions : BBF·Veit RoessnerAribert Rothenberger

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