Decreased Serum Sirtuin-1 in COPD

Chest
Satoru YanagisawaKazuhiro Ito

Abstract

The protein deacetylase sirtuin-1 (SIRT1) is an antiaging molecule that is decreased in the lung in patients with COPD. Recently, SIRT1 was reported to be detectable in serum, but serum SIRT1 (s120S) levels have not yet been reported in patients with COPD. Serum SIRT1 protein of all samples was measured by Western blot, and the SIRT1 protein band densities were calculated and compared with clinical parameters. Several molecular sizes of SIRT1, including 120 kDa (actual size) and fragments (102 and 75 kDa) were quantified by Western blot. Among them, only the 120-kDa s120S was significantly decreased in patients with COPD compared with the control subjects without COPD (s120S ratio in healthy subjects = 0.90 ± 0.34 vs those with COPD = 0.68 ± 0.24; P = .014) and was positively correlated with airway obstruction (FEV1/FVC, r = 0.31; P = .020); its severity measured by FEV1% predicted (r = 0.29; P = .029). s120S also showed a positive correlation with BMI (r = 0.36; P = .0077) and diffusing capacity of the lung per unit volume (the carbon monoxide transfer coefficient: KCO%) (r = 0.32; P = .025). It was also significantly decreased with increasing severity of lung emphysema (r = -0.40; P = .027) and with a clinical history of freq...Continue Reading

Citations

Dec 8, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Corry-Anke BrandsmaWim Timens
Nov 6, 2018·Journal of Cellular Biochemistry·Sadiya Bi ShaikhYashodhar Prabhakar Bhandary
Mar 6, 2019·Allergy·Peter J Barnes
Nov 26, 2019·Journal of Cellular and Molecular Medicine·Na-Rae ShinIn-Sik Shin
Dec 25, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yasuhiro GonMari Hikichi
Apr 25, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Paula Rodriguez-MiguelezRyan A Harris
May 13, 2020·Journal of Physical Activity & Health·Emmanuel Gomes CiolacRodolfo Paula Vieira
Jul 31, 2020·Expert Review of Respiratory Medicine·Peter J Barnes
Jul 16, 2020·Annals of the Rheumatic Diseases·George BatshonMona Dvir-Ginzberg
Oct 12, 2018·International Journal of Molecular Sciences·Alessia Mongelli, Carlo Gaetano
Jan 7, 2019·European Journal of Medicinal Chemistry·Priscila Baltazar Gonçalves, Nelilma Correia Romeiro
Jun 5, 2021·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Hassan GhobadiMohammad Reza Aslani
Aug 14, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Fuquan WangHaifa Xia

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

Statcel

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.