Decreased severity of ethanol withdrawal behaviors in kainic acid-treated rats

Pharmacology, Biochemistry, and Behavior
I MatsumotoP Wilce

Abstract

The involvement of kainate (KA)-sensitive regions in ethanol withdrawal behaviors was investigated in male Wistar rats given three intraperitoneal (IP) injections of KA (12 mg/kg) or saline each followed by recovery at 4 degrees C for 5 h and room temperature for 3 days and a final KA or saline injection at room temperature. Some animals received MK-801 (1 mg/kg, IP) 30 min after each injection and one group received saline only. The saline/saline, saline/MK-801, and KA/MK-801 groups displayed typical ethanol withdrawal behaviors 8-12 h after ethanol withdrawal. These behaviors were attenuated in the KA/saline group. Audiogenic seizures could be induced in all treatment groups 12 h after withdrawal. There was severe neuronal degeneration in the hippocampal CA region and the piriform cortex of the KA/saline-treated animals that was reduced by MK-801 treatment. The inferior colliculus remained intact. These results suggest that the N-methyl-D-aspartate receptor mediates KA-induced damage in limbic structures and that these regions may play an important role in typical, but not audiogenically induced ethanol-withdrawal behaviors.

References

Jun 1, 1992·Alcoholism, Clinical and Experimental Research·W R ProctorT V Dunwiddie
Mar 12, 1992·European Journal of Pharmacology·P F MorganM Linnoila
Jun 1, 1991·Alcoholism, Clinical and Experimental Research·K J Buck, R A Harris
Aug 2, 1990·European Journal of Pharmacology·P ValveriusB Tabakoff
Feb 13, 1990·European Journal of Pharmacology·K A GrantB Tabakoff
Mar 31, 1989·Science·D M LovingerF F Weight
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·R BustoM D Ginsberg
Mar 1, 1974·Electroencephalography and Clinical Neurophysiology·D W Walker, S F Zornetzer
Sep 1, 1980·Analytical Biochemistry·P J Munson, D Rodbard
Jan 1, 1994·Progress in Neurobiology·G Sperk

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