Decreased somal size of deep layer 3 pyramidal neurons in the prefrontal cortex of subjects with schizophrenia

Archives of General Psychiatry
J N PierriD A Lewis

Abstract

Schizophrenia is associated with deficits in working memory, a cognitive function that depends on the connections of the prefrontal cortex (PFC) with the thalamus and other cortical regions. Pyramidal neurons in PFC deep layer 3 play a central role in both thalamocortical and corticocortical circuitry. Given that somal size tends to be associated with both the dendritic and axonal architecture of a neuron, abnormalities in these circuits in schizophrenia may be associated with a change in the somal size of deep layer 3 pyramidal neurons. We used design-based stereology to estimate the somal volume of pyramidal neurons in deep layer 3 of PFC area 9 in 28 subjects with schizophrenia, each of whom was matched to 1 normal comparison subject for sex, age, and postmortem interval. The geometric mean of the somal volume estimates in the subjects with schizophrenia was significantly (P =.02) decreased by 9.2%. This decrease was associated with a shift in the distribution of somal volumes toward smaller sizes. Neither antipsychotic medication treatment history nor duration of illness was associated with somal size. These findings independently replicate previous reports of decreased somal size in the PFC in schizophrenia. The reduction ...Continue Reading

Citations

Jul 17, 2010·Biomechanics and Modeling in Mechanobiology·R J H ClootsM G D Geers
Mar 22, 2012·Biomechanics and Modeling in Mechanobiology·R J H ClootsM G D Geers
Aug 29, 2003·Journal of Abnormal Psychology·John G Kerns, Howard Berenbaum
Feb 1, 2010·Acta Neuropsychiatrica·Hubertus AxerKarl-Jürgen Bär
Nov 18, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kevin M SpencerRobert W McCarley
May 9, 2007·Archives of General Psychiatry·Dean F SalisburyRobert W McCarley
May 9, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert A SweetDavid A Lewis
Feb 19, 2009·Schizophrenia Bulletin·S Hossein Fatemi, Timothy D Folsom
Mar 27, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Dianne A CruzDavid A Lewis
Apr 3, 2009·The Journal of Clinical Investigation·David A Lewis, Robert A Sweet
Apr 27, 2010·Harvard Review of Psychiatry·Tsung-Ung W WooRobert W McCarley
Sep 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David A Lewis, Guillermo González-Burgos
Jun 17, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jill R Glausier, David A Lewis
Oct 5, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Robert E McCullumsmithJames H Meador-Woodruff
Mar 31, 2004·NeuroImage·Katherine L NarrRobert M Bilder
Jul 2, 2008·Expert Review of Neurotherapeutics·Ripu D Jindal, Matcheri S Keshavan
Sep 10, 2013·Child and Adolescent Psychiatric Clinics of North America·Benjamin K BrentLarry J Seidman
May 2, 2012·Neuroscience·J R Glausier, D A Lewis
Feb 7, 2012·Schizophrenia Research·John F SmileyCynthia Bleiwas
Dec 14, 2011·Trends in Neurosciences·David A LewisDavid W Volk
Nov 22, 2011·Journal of the Mechanical Behavior of Biomedical Materials·R J H ClootsM G D Geers
Apr 26, 2011·Progress in Neurobiology·Alfredo BellonThérèse M Jay
Jan 23, 2010·Journal of Psychiatric Research·Latchman Somenarain, Liesl B Jones
Aug 4, 2009·Neuroscience Letters·Hui-Pin LuPaul Wai-Fung Poon
Feb 19, 2008·Psychiatry Research·Manuel F CasanovaChristoph Schmitz
Mar 10, 2016·Harvard Review of Psychiatry·Joseph T CoyleGlenn T Konopaske
Jun 30, 2009·Proteomics·Jane A EnglishDavid R Cotter

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