Decreased steroid responsiveness at night in nocturnal asthma. Is the macrophage responsible?

American Journal of Respiratory and Critical Care Medicine
Monica KraftD Y Leung

Abstract

As peripheral blood mononuclear cells from patients with nocturnal asthma (NA) exhibit reduced steroid responsiveness at 4:00 A.M. as compared with 4:00 P.M., we hypothesized that NA is associated with increased nocturnal airway cell expression of GRbeta, an endogenous inhibitor of steroid action. Ten subjects with NA and seven subjects with nonnocturnal asthma (NNA) underwent bronchoscopy with bronchoalveolar lavage (BAL) at 4:00 P.M. and 4:00 A.M. BAL lymphocytes and macrophages were incubated with dexamethasone (DEX) at 10(-5) to 10(-8) M. DEX suppressed proliferation of BAL lymphocytes similarly at 4:00 P.M. and 4:00 A.M. in both groups. However, BAL macrophages from NA exhibited less suppression of IL-8 and TNF-alpha production by DEX at 4:00 A.M. as compared with 4:00 P.M. (p = 0.0001), whereas in the NNA group DEX suppressed IL-8 and TNF-alpha production equally at both time points. GRbeta expression was increased at night only in NA, primarily due to significantly increased expression by BAL macrophages (p = 0.008). IL-13 mRNA expression was increased at night, but only in the NA group and addition of neutralizing antibodies to IL-13 reduced GRbeta expression by BAL macrophages. We conclude that the airway macrophage ma...Continue Reading

References

Feb 1, 1979·Thorax·J R Bateman, S W Clarke
Jan 30, 1992·The New England Journal of Medicine·D S RobinsonA B Kay
Oct 1, 1991·The American Review of Respiratory Disease·P ChanezP Godard
Feb 1, 1991·The American Review of Respiratory Disease·R J MartinS J Szefler
May 1, 1991·The Journal of Clinical Investigation·Q HamidP K Jeffery
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·Q HamidJ M Polak
Dec 1, 1995·The Journal of Experimental Medicine·I M AdcockP J Barnes
Jun 1, 1995·The Journal of Clinical Investigation·C M BambergerG P Chrousos
Jul 1, 1994·American Journal of Respiratory and Critical Care Medicine·H YamamotoY Dohi
Apr 1, 1994·Allergy·S J LaneT H Lee
Dec 1, 1993·Annals of Internal Medicine·G P ChrousosM Karl
May 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A C Cato, E Wade
Jun 1, 1996·The Journal of Allergy and Clinical Immunology·M KraftR J Martin
Nov 1, 1996·American Journal of Respiratory and Critical Care Medicine·M KraftR J Martin
Oct 6, 1997·American Journal of Respiratory and Critical Care Medicine·S E WenzelR J Martin
Nov 14, 1997·The Journal of Experimental Medicine·D Y LeungD J Klemm
Dec 31, 1997·American Journal of Respiratory Cell and Molecular Biology·E M MinshallQ Hamid
Mar 11, 1998·Chronobiology International·M KraftR J Martin
Dec 18, 1998·Science·M Wills-KarpD D Donaldson
Feb 3, 1999·Molecular Pharmacology·M D GalignianaJ Assreuy
May 6, 1999·American Journal of Respiratory and Critical Care Medicine·Q A HamidD Y Leung
Feb 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H LiuR M Pope

❮ Previous
Next ❯

Citations

Apr 18, 2007·Current Allergy and Asthma Reports·Laura PujolsCésar Picado
Mar 17, 2004·Biochimica Et Biophysica Acta·W S Fred Wong, Khai Pang Leong
Apr 2, 2003·Journal of Neuroimmunology·Ning QuanJohn F Sheridan
Jan 28, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·David N PhamMonica Kraft
Dec 26, 2001·Current Opinion in Pulmonary Medicine·Gene L Colice
Nov 30, 2006·Current Opinion in Pulmonary Medicine·Hidenobu Shigemitsu, Kamyar Afshar
Mar 5, 2002·American Journal of Respiratory and Critical Care Medicine·Martin J Tobin
Oct 16, 2002·American Journal of Respiratory and Critical Care Medicine·E Rand SutherlandMonica Kraft
Jan 3, 2006·American Journal of Respiratory and Critical Care Medicine·Elena GolevaDonald Y M Leung
Mar 23, 2004·American Journal of Respiratory Cell and Molecular Biology·Ian R WitherdenTeresa D Tetley
Mar 16, 2012·Respiratory Research·Manminder KaurDave Singh
Aug 19, 2014·Clinical Reviews in Allergy & Immunology·Panida Sriaroon, Mark Ballow
Dec 5, 2015·Frontiers in Immunology·Aleksander Keselman, Nicola Heller
Nov 3, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C E BrightlingF Hollins
Jun 8, 2002·Paediatric Respiratory Reviews·W Lenney
Sep 15, 2014·Pulmonary Pharmacology & Therapeutics·C BoardmanP Sharma
Aug 29, 2006·Lancet·Sally E Wenzel
Sep 10, 2004·Allergy·L PujolsC Picado
Jan 16, 2018·Expert Opinion on Investigational Drugs·Polyxeni NtontsiGeorgios Hillas
May 19, 2010·Expert Review of Respiratory Medicine·Merritt L Fajt, Sally E Wenzel
Aug 5, 2011·The New England Journal of Medicine·Jonathan CorrenJohn G Matthews
Apr 23, 2016·Annals of the American Thoracic Society·Kimberly K TruongAtul Malhotra
Jan 18, 2003·The Journal of Allergy and Clinical Immunology·Donald Y M Leung, John W Bloom
Oct 4, 2005·Respiratory Physiology & Neurobiology·Musa A HaxhiuPrabha Kc
Dec 13, 2006·International Immunopharmacology·Toshihiko Hirano
Sep 29, 2007·Advanced Drug Delivery Reviews·Michael H SmolenskyAlain E Reinberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

Related Papers

American Journal of Respiratory and Critical Care Medicine
Monica KraftR J Martin
© 2021 Meta ULC. All rights reserved