PMID: 11912398Mar 26, 2002Paper

Decreased suburethral prostatic microvessel density in finasteride treated prostates: a possible mechanism for reduced bleeding in benign prostatic hyperplasia

The Journal of Urology
David A HochbergJohn A Fracchia

Abstract

We evaluated the influence of finasteride on prostatic microvessel density to elucidate a mechanism of decreased bleeding in finasteride treated patients with hematuria secondary to benign prostatic hyperplasia (BPH). A total of 22 patients with clinical BPH and gross hematuria who underwent prostate reductive surgery between 1998 and 2000 were prospectively evaluated. The prostate from 10 finasteride treated and 12 untreated patients was immunohistochemically stained for CD-34. Microvessel density analysis was performed by quantifying positive stained blood vessels located within the stroma of hyperplastic nodules as well as in the suburethral portion of the prostate. Mean microvessel density plus or minus standard deviation in finasteride treated patients was significantly lower in the suburethral portion of the prostate versus untreated controls (14.0 +/- 2.8 versus 20.2 +/- 5.3 vessels per high power field, p <0.05). In the nodular hyperplasia there was no statistically significant difference in the treatment and control groups (mean 17.5 +/- 2.8 and 16.7 +/- 4.6 vessels per high power field, respectively). Finasteride significantly decreases suburethral prostatic microvessel density in patients with BPH, which may explain ...Continue Reading

References

Mar 1, 1995·The Prostate·R E DeeringM K Brawer
Jan 5, 2000·BJU International·S J Foley, D M Bailey

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Citations

Feb 7, 2008·Nature Clinical Practice. Urology·Ardeshir R RastinehadLouis R Kavoussi
Feb 16, 2012·Prostate Cancer and Prostatic Diseases·F Azzouni, J Mohler
May 6, 2014·Life Sciences·Larissa Akemi KidoValéria Helena Alves Cagnon
Aug 17, 2016·International Journal of Molecular Sciences·Letteria MinutoliAntonio Micali
Sep 6, 2006·The Journal of Urology·Leonard S MarksGerald L Andriole
Aug 17, 2011·Nature Reviews. Urology·Liam E KavanaghUNKNOWN Medscape
May 14, 2017·Journal of Biomedical Science·Raquel Frenedoso da SilvaValéria Helena Alves Cagnon

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