Decreased suicide rates in recent antidepressant clinical trials

Psychopharmacology
Arif KhanWalter A Brown

Abstract

The last systematic analysis of suicidality in antidepressant clinical trials submitted for approval by the US Food and Drug Administration was in 2000. Given the attention to suicide and antidepressants in the early 2000s, the authors aimed to evaluate if there have been any changes in suicide rates in antidepressant clinical trials following 2000. The Integrated Safety Summary data from approval packets for 14 investigational antidepressant programs (1991-2013, 40,857 patients, 10,890.5 exposure years) were used to calculate suicides and suicide attempts per 100,000 patient exposure years (standardized rates) for antidepressant and placebo treatment groups separately. Suicides/suicide attempt rates, mean age, and percent female were compared between 1991 and 1998 (pre-2000) and 2002-2013 (post-2000). Drug-placebo differences in suicide/suicide attempt rates were explored. Among antidepressant-treated patients, the standardized suicide rate decreased significantly from pre- to post-2000 (643.6 to 25.8, p < 0.0001) as did the standardized suicide attempt rate (3975.7 to 645.4, p < 0.0001). For placebo-treated patients, the decrease was not significant for suicide rate (471.1 to 174.2, p = 0.66) but was significant for suicide a...Continue Reading

References

Feb 1, 1990·The American Journal of Psychiatry·M H TeicherJ O Cole
Aug 9, 2006·Archives of General Psychiatry·Mark OlfsonDavid Shaffer

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Citations

Sep 25, 2018·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Arif KhanWalter A Brown
Jun 17, 2020·The International Journal of Risk & Safety in Medicine·Tomaž Makovec
May 20, 2021·The Journal of Nervous and Mental Disease·Valentina SacchiGian Maria Galeazzi
Sep 6, 2019·Psychotherapy and Psychosomatics·Joseph F HayesGlyn Lewis
Jun 25, 2019·Psychotherapy and Psychosomatics·Michael P Hengartner, Martin Plöderl

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Methods Mentioned

BETA
ISS

Software Mentioned

PEY
Statistical Package for the Social Sciences ( SPSS

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