PMID: 6108036Nov 1, 1980Paper

Decreased testicular response to acute LH-stimulation and increased intratesticular concentration of oestradiol-17 beta in the abdominal testes in cryptorchid rats

Acta Endocrinologica
J E Damber, A Bergh

Abstract

Rats were made cryptorchid, bi- or unilaterally, by cutting gubernaculum testis at birth. At 100 days of age the basal plasma testosterone concentration was smaller in bilateral cryptorchid animals as compared to unilateral cryptorchid and control rats. After acute LH-stimulation plasma testosterone concentration increased in all rats, where the highest concentrations were found in the control group. The amount of testosterone in the testis after a 30 min LH-stimulation was lower in both kinds of cryptorchid testes but higher in the scrotal testis of the unilateral cryptorchid rats, all as compared to control testis. This decreased effect of LH observed in cryptorchid animals indicates an impaired Leydig cell function in cryptorchid testis. The results also show a compensatory hyperfunction of Leydig cells in the scrotal testes of unilateral cryptorchid rats. It was also found that the intratesticular concentration of oestradiol-17 beta was three-fold increased in unilateral cryptorchid testes and even more in bilateral cryptorchid ones.

Citations

Jan 1, 1989·Journal of Steroid Biochemistry·N MouhadjerM Bedin
Jan 1, 1983·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·C P SomervilleE J Keogh
Jan 1, 1986·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·R Hatier, G Grignon
Feb 1, 1982·International Journal of Andrology·B KarpeE M Ritzén
Oct 1, 1984·International Journal of Andrology·A Bergh, J E Damber
Nov 24, 1999·The Journal of Veterinary Medical Science·E KawakamiT Tsutsui
Apr 1, 1986·The Anatomical Record·J E Anderson, J A Thliveris
Jan 1, 1982·Clinical Endocrinology·F C WuD T Baird
Dec 1, 1983·Archives of Andrology·J E DamberR Södergård
Feb 28, 2021·Molecular and Cellular Endocrinology·Rashid A Aldahhan, Peter G Stanton

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