Decreased TrkA gene expression in cholinergic neurons of the striatum and basal forebrain of patients with Alzheimer's disease

Experimental Neurology
F BoissièreE C Hirsch

Abstract

In addition to cortical pathology, Alzheimer's disease is characterized by a loss of cholinergic neurons in the basal forebrain and the ventral striatum. Since cholinergic neurons which degenerate in Alzheimer's disease are sensitive to nerve growth factor, a link between nerve growth factor sensitivity and the vulnerability of cholinergic neurons has been suspected. The purpose of this study was to determine, in cholinergic neurons, the level of expression of TrkA, the high affinity receptor for nerve growth factor, in control subjects and Alzheimer patients. The study was performed by in situ hybridization using a 35S-labeled RNA probe complementary to human TrkA mRNA on immunohistochemically identified cholinergic neurons of the nucleus basalis of Meynert, the ventral striatum, and the putamen in postmortem brains of patients with clinically and neuropathologically confirmed Alzheimer's disease and control subjects. In patients with Alzheimer's disease, a decrease in TrkA mRNA expression was observed in the nucleus basalis of Meynert (-75%, P < 0.001) and the ventral striatum (-41%, P < 0.01), where the cholinergic neurons degenerate, and also in the anterior (-43%, P < 0.01) and posterior (-51%, P < 0.01) parts of the putam...Continue Reading

References

Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·O StradaF Javoy-Agid
Apr 1, 1989·Trends in Pharmacological Sciences·C F Dreyfus
Jun 1, 1982·Brain : a Journal of Neurology·M N RossorL L Iversen
Nov 1, 1994·The Journal of Comparative Neurology·J H KordowerE J Mufson

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Citations

Oct 17, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·C Anthony AltarStephen D Ginsberg
Aug 28, 1999·Genetic Testing·S L TobinL M McConnell
Mar 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Efrain Sanchez-OrtizLuis F Parada
Sep 25, 2003·Neurological Research·Dick F Swaab
Aug 11, 2016·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Stefan TeipelUNKNOWN FTLDc study group
Jan 17, 2002·The Journal of Comparative Neurology·Elliott J MufsonJeffrey H Kordower
Sep 18, 2008·Journal of Neurochemistry·Bettina SobottkaFriedrich Metzger
Apr 6, 2005·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Yossef S LevyDaniel Offen
Aug 27, 2013·Nature Reviews. Drug Discovery·Frank M Longo, Stephen M Massa
Aug 19, 1999·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·A J Stoessl
Dec 12, 2013·Journal of Gastroenterology and Hepatology·Youn-Kyung BakMi-Kyung Sung
Jul 6, 2014·Frontiers in Molecular Neuroscience·Pilar Rivero-RíosSabine Hilfiker
Dec 16, 2011·Physiology·Karen P Maruska, Russell D Fernald
Jun 13, 2000·Alzheimer Disease and Associated Disorders·M E Jönhagen
Jun 13, 2000·Alzheimer Disease and Associated Disorders·T Nabeshima, K Yamada
Jun 6, 2003·Neuropathology and Applied Neurobiology·D Dawbarn, S J Allen
Oct 28, 2019·American Journal of Alzheimer's Disease and Other Dementias·Xinhui LiLi An
Sep 27, 2003·Alzheimer Disease and Associated Disorders·D F SwaabR W H Verwer
Apr 13, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R HellwegJ Cervós-Navarro
May 29, 1998·Progress in Neurobiology·N J Woolf

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