Decreased vasoconstrictor responses in remote cerebral arteries after focal brain ischemia and reperfusion in the rat, in vitro

European Journal of Pharmacology
Anikó KovácsGábor Szénási

Abstract

The effects of brain ischemia and reperfusion on smooth muscle function in remote cerebral and peripheral arteries are hardly known. Maximum vasoconstrictions (E(max)) caused by 120mmol/l KCl and 5-HT in endothelium-denuded ring preparations were measured in ischemic and control cerebral arteries of rats after a 1-h right middle cerebral artery occlusion followed by 0-min (I/NR) or 2-3-min (I/SR) reperfusion, and in peripheral arteries after I/SR. Surprisingly, vasoconstrictions to 5-HT and 120mmol/lK(+) were attenuated in remote brain vessels after I/SR, i.e. in the contralateral middle cerebral artery and the basilar artery, while I/NR depressed E(max) of 5-HT and high KCl only in the ischemic middle cerebral artery. Pretreatment with N-(2-mercaptopropionyl) glycine (MPG, 100mg/kg i.p.), a free radical scavenger, fully prevented the impairment of vasomotor function in the middle cerebral artery on both sides after I/SR. Moreover, vasomotor functions were normal in the coronary, renal and pulmonary arteries after I/SR. In conclusion, focal cerebral ischemia and reperfusion impaired vasoconstrictor responses in remote brain arteries of rats by a mechanism involving free radicals. The lack of similar effects in peripheral vessel...Continue Reading

References

Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
Jun 6, 2000·Trends in Pharmacological Sciences·A Rubino, D M Yellon
Aug 3, 2002·Stroke; a Journal of Cerebral Circulation·Marilyn J Cipolla, Amy B Curry
Sep 7, 2002·Stroke; a Journal of Cerebral Circulation·Emelie StenmanLars Edvinsson
Mar 6, 2004·Stroke; a Journal of Cerebral Circulation·Emelie Stenman, Lars Edvinsson
Jul 9, 2004·British Journal of Pharmacology·Marie HenrikssonLars Edvinsson
Feb 26, 2005·Stroke; a Journal of Cerebral Circulation·Hui XieBillie Lou Short
May 27, 2005·The Journal of Surgical Research·Yih-Sharng ChenChau-Fong Chen
Jun 28, 2005·Annals of Vascular Surgery·John B Seal, Bruce L Gewertz
Sep 9, 2006·Seminars in Cardiothoracic and Vascular Anesthesia·Guy R Heyndrickx
Aug 8, 2007·Pharmacology & Therapeutics·Derek J Hausenloy, Derek M Yellon
Sep 28, 2007·Endocrine, Metabolic & Immune Disorders Drug Targets·Craig S BolteJo El J Schultz
Jan 24, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·George Trendelenburg
Feb 9, 2008·The Journal of Pharmacology and Experimental Therapeutics·Sonia Martinez-RevellesElisabet Vila

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Ischemia

Brain ischemia is a condition in which there is insufficient blood flow to the brain to meet metabolic demand. Discover the latest research on brain ischemia here.