PMID: 9192226Jun 1, 1997Paper

Decreased white fat cell thermogenesis in obese individuals

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
H Böttcher, P Fürst

Abstract

To investigate whether white adipocyte thermogenesis and energy metabolism are reduced in obese individuals. Eight lean and 15 obese men and women; BMI 19-41. Isolated subcutaneous adipocytes were maintained in agarose gel for 20h under basal conditions and subsequently for 10h after stimulation with 1 microM isoprenaline. Direct microcalorimetry was performed continuously over 30h while biochemical measures were obtained after 0, 20, 25 and 30h. Total cellular thermogenesis, oxygen consumption, glycolysis, lipolysis, triglyceride/FFA substrate cycle, adenine nucleotides, DNA content as basis of reference. Under basal and stimulated conditions, thermogenesis (5.6 and 8.6 microW/microgDNA, respectively; P < 0.0001) correlated negatively (P < 0.01 and P < 0.05, respectively) with the BMI and positively with O2 and glucose consumption, lactate, glycerol, FFA release and FFA re-esterification. Reduced basal lactate production with increased BMI (P < 0.05) indicates a more aerobic adipocyte metabolism in obese individuals. Negative correlation between BMI and stimulated triglyceride/FFA substrate cycle activity (P < 0.01) explains the decreased hormone induced adipocyte heat production in the obese. The results suggest that a reduct...Continue Reading

Citations

May 20, 1998·Baillière's Clinical Endocrinology and Metabolism·H Böttcher, P Fürst
May 8, 2009·International Journal of Biological Sciences·Shinobu MoriToshihiko Yada
Dec 4, 2013·Nature Reviews. Endocrinology·Sheila Collins
Nov 9, 2011·Neuropharmacology·John C Clapham
Jul 12, 2003·Obesity Research·Tong WangWen Guo
Nov 17, 2009·Biochemical and Biophysical Research Communications·Takahiro YamakawaKeiichi Itakura
Oct 15, 2014·Biochimica Et Biophysica Acta·Mojgan MasoodiJan Kopecky
Nov 22, 2013·Journal of Lipid Research·Lea DibSheila Collins
Nov 26, 2009·Experimental Biology and Medicine·Shinobu MoriToshihiko Yada
Mar 21, 2018·Lipids in Health and Disease·Maysa M CruzMaria I C Alonso-Vale
Dec 14, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·M RossmeislJ Kopecky
Jan 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Shannon P Reidy, Jean-Michel Weber
Jul 15, 2006·Endocrinology·Josep MercaderAndreu Palou
Jun 25, 2002·Annals of the New York Academy of Sciences·Jan KopeckýJana Sponarová
Feb 8, 2007·American Journal of Physiology. Endocrinology and Metabolism·Yaguang SiKyongbum Lee
Aug 18, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ya-Wen WangZhen-Yu Du
Jun 18, 2015·American Journal of Physiology. Endocrinology and Metabolism·Britta FischerThomas Skurk
Oct 2, 2020·Reviews in Endocrine & Metabolic Disorders·Leandro Henrique Manfredi
May 5, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·S P Reidy, J Weber

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