Decreasing birth weight is associated with adverse metabolic profile and lower stature in childhood and adolescence

PloS One
J G B DerraikP L Hofman

Abstract

We aimed to evaluate the association of birth weight SDS with insulin resistance, blood pressure, and auxology in children and adolescents born 23-42 weeks of gestation. We studied 143 singleton children and adolescents aged 9.3 ± 3.3 years (range 2.0-17.9 years). Clinical assessments included insulin resistance measured by HOMA2-IR, auxology, and blood pressure from sphygmomanometer measurements. Continuous associations were examined, and stratified analyses carried out. For the latter, participants were divided into those of below-average birth weight (BABW, <0 SDS) and above-average birth weight (AABW, ≥0 SDS). Irrespective of gestational age, lower birth weight SDS was associated with progressively greater HOMA2-IR (p<0.0001) and higher fasting insulin concentrations (p<0.0001). Decreasing birth weight SDS was associated with higher systolic (p = 0.011) and diastolic (p = 0.006) blood pressure. Lower birth weight SDS was also associated with decreasing stature (p<0.010). The BABW group was ~40% more insulin resistant than AABW participants (p = 0.004), with the former also displaying fasting insulin concentrations 37% higher (p = 0.004). BABW participants were 0.54 SDS shorter than those of higher birth weight (p = 0.002). ...Continue Reading

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Citations

Aug 6, 2017·Journal of the American Heart Association·Andraea Van HulstMélanie Henderson
Aug 24, 2018·The Journal of Clinical Endocrinology and Metabolism·Andraea Van HulstMélanie Henderson

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Methods Mentioned

BETA
SGA

Software Mentioned

SAS
Minitab
HOMA2

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