Decreasing glioma recurrence through adjuvant cancer stem cell inhibition.

Biologics : Targets & Therapy
Josh Neman, Rahul Jandial

Abstract

Gliomas remain one of the most challenging solid organ tumors to treat and are marked clinically by invariable recurrence despite multimodal intervention (surgery, chemotherapy, radiation). This recurrence perhaps, is as a consequence of the failure to eradicate a tumor cell subpopulation, termed cancer stem cells. Isolating, characterizing, and understanding these tumor-initiating cells through cellular and molecular markers, along with genetic and epigenetic understanding will allow for selective targeting through therapeutic agents and holds promise for decreasing glioma recurrence.

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Citations

Jan 27, 2015·International Journal of Cancer. Journal International Du Cancer·Virginie LamourAkeila Bellahcène

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Methods Mentioned

BETA
xenografts
xenograft

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