Decreasing mortality and changes in treatment patterns in patients with acromegaly from a nationwide study

European Journal of Endocrinology
Daniela EspositoDaniel S Olsson

Abstract

New therapeutic strategies have developed for the management of acromegaly over recent decades. Whether this has improved mortality has not been fully elucidated. The primary aim was to investigate mortality in a nationwide unselected cohort of patients with acromegaly. Secondary analyses included time trends in mortality and treatment patterns. A total of 1089 patients with acromegaly were identified in Swedish National Health Registries between 1987 and 2013. To analyse time trends, the cohort was divided into three periods (1987-1995, 1996-2004 and 2005-2013) based on the year of diagnosis. Using the Swedish population as reference, standardized mortality ratios (SMRs) were calculated with 95% confidence intervals (CIs). Overall SMR was 2.79 (95% CI: 2.43-3.15) with 232 observed and 83 expected deaths. Mortality was mainly related to circulatory diseases (SMR: 2.95, 95% CI: 2.35-3.55), including ischemic heart disease (2.00, 1.35-2.66) and cerebrovascular disease (3.99, 2.42-5.55) and malignancy (1.76, 1.27-2.26). Mortality decreased over time, with an SMR of 3.45 (2.87-4.02) and 1.86 (1.04-2.67) during the first and last time period, respectively (P = .015). During the same time periods, the frequency of pituitary surgery i...Continue Reading

References

Mar 1, 1993·Journal of Endocrinological Investigation·J EtxabeJ A Vazquez
Jul 10, 2001·The Journal of Clinical Endocrinology and Metabolism·S Melmed
Jan 25, 2003·BMJ : British Medical Journal·Douglas G Altman, J Martin Bland
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Ian M HoldawayGreg D Gamble
Feb 11, 2004·Endocrine Reviews·Annamaria ColaoGaetano Lombardi
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Nienke R BiermaszFerdinand Roelfsema
Nov 9, 2004·The Journal of Clinical Endocrinology and Metabolism·Nienke R BiermaszFerdinand Roelfsema
Mar 3, 2005·The Journal of Clinical Endocrinology and Metabolism·Nienke R BiermaszFerdinand Roelfsema
Dec 15, 2006·The New England Journal of Medicine·Shlomo Melmed
Sep 26, 2007·European Journal of Endocrinology·Marie BexDominique Maiter
Nov 1, 2007·The Journal of Clinical Endocrinology and Metabolism·O M DekkersJ P Vandenbroucke
Jan 21, 2010·Endocrine Reviews·Mark SherlockPaul M Stewart
Jun 11, 2011·BMC Public Health·Jonas F LudvigssonPetra Otterblad Olausson
May 19, 2012·European Journal of Endocrinology·M ArosioUNKNOWN Italian Study Group of Acromegaly
Jul 24, 2012·Pituitary·Leandro KasukiMônica R Gadelha
Oct 23, 2012·European Journal of Endocrinology·Christof SchöflUNKNOWN participants of the German Acromegaly Register
Nov 30, 2012·Clinical Endocrinology·Sophie ValletteOmar Serri
Mar 5, 2014·European Journal of Endocrinology·B DelemerF Castinetti
Aug 3, 2014·European Journal of Endocrinology·Axel TjörnstrandHelena Filipsson Nyström
Oct 31, 2014·The Journal of Clinical Endocrinology and Metabolism·Laurence KatznelsonJohn A H Wass
Nov 7, 2014·The Journal of Clinical Endocrinology and Metabolism·Daniel S OlssonGudmundur Johannsson
Dec 3, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Bernadette PinterWerner Poewe
Feb 7, 2015·The Journal of Clinical Endocrinology and Metabolism·Joseph M PappachanRichard N Clayton
May 7, 2015·The Journal of Clinical Endocrinology and Metabolism·Daniel S OlssonEva Andersson
Jan 23, 2016·Pituitary·Tanya BurtonWilliam H Ludlam
Apr 20, 2016·European Journal of Endocrinology·Cesar Luiz Boguszewski, John Ayuk
May 18, 2016·Endocrine-related Cancer·Elina RitvonenCamilla Schalin-Jäntti
Jun 10, 2016·European Journal of Endocrinology·Jakob DalJens Otto L Jørgensen
Mar 2, 2017·European Journal of Endocrinology·Luigi MaioneUNKNOWN French Acromegaly Registry Group
Jul 25, 2017·Endocrine-related Cancer·Patrick PetrossiansAlbert Beckers
Aug 29, 2017·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Konstantina KousoulaOskar Ragnarsson

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Citations

May 17, 2018·European Journal of Endocrinology·F BolfiV S Nunes-Nogueira
Feb 5, 2019·The Journal of Clinical Endocrinology and Metabolism·Oskar RagnarssonGudmundur Johannsson
Sep 29, 2019·Journal of Clinical Medicine·Betina BiagettiRafael Simó
Dec 25, 2019·The Journal of Clinical Endocrinology and Metabolism·Nicholas A Tritos
Feb 12, 2020·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Nidan QiaoNicholas A Tritos
Jun 27, 2020·The Journal of Clinical Endocrinology and Metabolism·Eva C CoopmansSebastian J C M M Neggers
Jul 28, 2020·Pituitary·Wael M AlmistehiSyed Ali Imran
Jan 16, 2020·Archives of Endocrinology and Metabolism·Leandro KasukiMônica Roberto Gadelha
Jan 16, 2020·Archives of Endocrinology and Metabolism·Raquel S Jallad, Marcello D Bronstein
Aug 28, 2020·Clinical Diabetes and Endocrinology·Lima LawrenceDivya Yogi-Morren
Mar 23, 2019·Nature Reviews. Disease Primers·Annamaria ColaoRosario Pivonello
Dec 1, 2018·Endocrine Reviews·Cesar Luiz Boguszewski, Margaret Cristina da Silva Boguszewski
Aug 25, 2020·International Journal of Endocrinology·Jing GuZhiwen Yin
Dec 4, 2019·Expert Review of Endocrinology & Metabolism·Angeline Jia Jia ShenChristopher J Yates
Oct 21, 2020·Pituitary·Maria FleseriuShlomo Melmed
Mar 22, 2019·Best Practice & Research. Clinical Endocrinology & Metabolism·Luigi Maione, Philippe Chanson
Aug 4, 2021·The Journal of Clinical Endocrinology and Metabolism·Daniela EspositoDaniel S Olsson

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