Decreasing radiation therapy utilization in adult patients with glioblastoma multiforme: a population-based analysis.

Cancer
Gary V WalkerPaul D Brown

Abstract

The purpose of this study was to assess what factors influence radiation therapy (RT) utilization in patients with glioblastoma and to ascertain how patterns of care have changed over time. A total of 9103 patients with supratentorial glioblastoma in the Surveillance, Epidemiology, and End Results (SEER) database from 1973 to 2006 were analyzed. Demographic information was obtained, including age, sex, race, year of diagnosis, and marital status. Treatment characteristics included receipt of RT and surgical resection. In total, 76.8% of patients received RT, whereas 78% received resection. Patients of male sex, who were currently married, who were <65 years old, and who underwent resection were more likely to receive RT. The average annual percentage change in RT utilization in the years 1990-2006 was -0.41% (95% confidence interval [CI], -0.23 to -0.58), whereas for resection it was 0.26% (95% CI, 0.03 to 0.50). This equates to a 6.5% decrease in RT utilization and a 4.2% increase in resection during this time period. Patients treated with RT had a 2-year overall survival of 11.4%, compared with 5.2% in those not treated with RT (P < .00001). Multivariate analysis showed that younger age (continuous; odds ratio [OR], 0.97; P <...Continue Reading

References

Aug 21, 2002·Medical Care·Beth A VirnigJean Freeman
Jul 25, 2003·Cancer·Jill S Barnholtz-SloanAnn G Schwartz
Jan 28, 2004·Neurosurgery·N Scott LitofskyUNKNOWN Glioma Outcomes Project Investigators
Oct 12, 2004·Cancer·Kenneth R HessMelissa L Bondy
Mar 11, 2005·The New England Journal of Medicine·Roger StuppUNKNOWN National Cancer Institute of Canada Clinical Trials Group
Sep 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anneke T SchroenCraig L Slingluff
Jul 4, 2006·International Journal of Radiation Oncology, Biology, Physics·Rinaa S PungliaCraig C Earle
Apr 13, 2007·The New England Journal of Medicine·Florence Keime-GuibertUNKNOWN Association of French-Speaking Neuro-Oncologists
May 29, 2007·Journal of Neuro-oncology·Jill S Barnholtz-SloanAndrew E Sloan
Jul 13, 2007·The New England Journal of Medicine·Stephen Hanna
Oct 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Douglas M HousmanLynn D Wilson
Dec 25, 2008·Annals of Neurology·Fabio M IwamotoLauren E Abrey
Nov 26, 2010·Journal of the National Cancer Institute·Alasdair G RooneyRobin Grant
Aug 27, 2011·The Lancet Oncology·Pieter L KubbenHenk van Santbrink

❮ Previous
Next ❯

Citations

Mar 5, 2016·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Katherine E SchwetyeSonika Dahiya
Mar 7, 2014·Head & Neck·Eric W SchaeferChristopher S Hollenbeak
Nov 5, 2014·Current Opinion in Neurology·Adelheid WoehrerJill S Barnholtz-Sloan
Oct 27, 2016·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Florian PutzRainer Fietkau
Oct 10, 2015·Oncotarget·Kamran A AhmedJimmy J Caudell
Dec 26, 2012·Journal of Neuro-oncology·Gary V WalkerMary Frances McAleer
Feb 6, 2017·Journal of Neuro-oncology·Maryam ShabihkhaniWilliam H Yong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.