Decreasing the Ratio of Dietary Linoleic to α-Linolenic Acid from 10 to 4 by Changing Only the Former Does Not Prevent Adiposity or Bone Deterioration in Obese Mice

The Journal of Nutrition
Jay J CaoMatthew J Picklo

Abstract

Linoleic acid (LA; 18:2n-6) has been considered to promote low-grade chronic inflammation and adiposity. Studies show adiposity and inflammation are inversely associated with bone mass. This study tested the hypothesis that decreasing the dietary ratio of LA to α-linolenic acid (ALA, 18:3n-3), while keeping ALA constant, mitigates high-fat diet (HF)-induced adiposity and bone loss. Male C57BL/6 mice at 6 wk old were assigned to 4 treatment groups and fed 1 of the following diets ad libitum for 6 mo: a normal-fat diet (NF; 3.85 kcal/g and 10% energy as fat) with the ratio of the PUFAs LA to ALA at 6; or HFs (4.73 kcal/g and 45% energy as fat) with the ratio of LA to ALA at 10:1, 7:1, or 4:1, respectively. ALA content in the diets was kept the same for all groups at 1% energy. Bone structure, body composition, bone-related cytokines in serum, and gene expression in bone were measured. Data were analyzed using 1-factor ANOVA. Compared with those fed the NF, mice fed the HFs had 19.6% higher fat mass (P < 0.01) and 13.5% higher concentration of serum tartrate-resistant acid phosphatase (TRAP) (P < 0.05), a bone resorption cytokine. Mice fed the HFs had 19.5% and 12.2% lower tibial and second lumbar vertebral bone mass, respectively...Continue Reading

References

Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Jun 14, 1993·Annals of the New York Academy of Sciences·I HainaultM Lavau
Jun 9, 2001·Experimental Biology and Medicine·B A WatkinsM F Seifert
Feb 15, 2002·Current Opinion in Clinical Nutrition and Metabolic Care·J Thomas Brenna
Sep 11, 2002·The Journal of Nutrition·Hope A Weiler, Shirley C Fitzpatrick-Wong
Jul 12, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Dongxu SunGabriel Fernandes
Nov 4, 2004·The British Journal of Nutrition·M KorotkovaB Strandvik
Apr 9, 2005·The American Journal of Clinical Nutrition·Lauren A WeissDenise von Mühlen
Dec 21, 2005·The Journal of Nutrition·Rebecca L CorwinBarry I Graubard
Sep 12, 2006·The Journal of Nutritional Biochemistry·Arunabh BhattacharyaGabriel Fernandes
Dec 15, 2006·Nature·Gökhan S Hotamisligil
Oct 19, 2007·Journal of Cardiovascular Medicine·Walter C Willett
Jan 30, 2009·The Journal of Nutrition·Tae-Wook KyungHye-Seon Choi
Jun 10, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mary L BouxseinRalph Müller
Mar 4, 2011·The American Journal of Clinical Nutrition·Tanya L BlasbalgRobert R Rawlings
Aug 26, 2011·World Review of Nutrition and Dietetics·Jing X Kang
Jun 19, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jin-Ran ChenMartin J J Ronis
Jul 6, 2013·Nutrition Research·Owen J KellyJasminka Z Ilich
Jun 29, 2016·Prostaglandins & Other Lipid Mediators·Shaan S NaughtonAndrew J McAinch
Apr 12, 2019·Circulation·Matti MarklundUNKNOWN Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCE)

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Citations

Sep 24, 2021·Phytotherapy Research : PTR·Qianghua YuanLi Liu

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