Decreasing undesirable absorbed radiation to the intestine after administration of radium-223 dichloride for treatment of bone metastases.

Scientific Reports
Kazuma OgawaSeigo Kinuya

Abstract

[223Ra]RaCl2 is the first alpha-particle emitting radiopharmaceutical to be used for castration-resistant prostate cancer patients with bone metastases because of its excellent therapeutic effects. [223Ra]RaCl2 is excreted via the intestine into feces, and some is absorbed from the intestine into the blood, which may be undesirable in terms of the exposure to radiation. Recently, we showed that a complex of myo-inositol-hexakisphosphate (InsP6) with zinc is a useful decorporation agent against radiostrontium. In this study, we hypothesized that Zn-InsP6 could bind to not only strontium but also to radium, and could inhibit the absorption of radium from the intestine. In in vitro binding experiments, Zn-InsP6 showed a high binding affinity for radium. In in vivo biodistribution experiments by intravenous injection of [223Ra]RaCl2 after treatment of Zn-InsP6, mice treated with Zn-InsP6 showed significantly lower bone accumulation of radioactivity (34.82 ± 1.83%Dose/g) than the mice in the non-treatment control group (40.30 ± 2.78%Dose/g) at 48 h postinjection. These results indicate that Zn-InsP6 bound radium in the intestine and inhibited the absorption of radium into the blood. Therefore, the insoluble Zn-InsP6 complex has high...Continue Reading

References

Jan 1, 1990·Free Radical Biology & Medicine·E Graf, J W Eaton
Aug 25, 1999·The Journal of Nutrition·K MoritaT Hasegawa
Jun 5, 2003·International Immunopharmacology·Mary L S QueirozSolange Malacrida
Jan 1, 1962·The American Journal of Medicine·N L WOODARD HQ HIGINBOTHAM
Jun 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sten NilssonOyvind S Bruland
Jan 13, 2006·Journal of Animal Physiology and Animal Nutrition·T Szkudelski
Jan 19, 2006·Nature Structural & Molecular Biology·Deirdre Scadden
Mar 22, 2007·The Journal of Nutrition·K Michael Hambidge, Nancy F Krebs
Sep 20, 2008·Journal of Medicinal Food·Jae-Young ShimAe-Son Om
Dec 18, 2009·Nutrition Research and Practice·Jee Ae ShimMi Kyung Kim
Jun 6, 2012·Current Medicinal Chemistry·K Ogawa, K Washiyama
May 9, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Jorge A CarrasquilloMichael J Morris
Jul 19, 2013·The New England Journal of Medicine·C ParkerUNKNOWN ALSYMPCA Investigators
Jun 16, 2015·BioMed Research International·Kazuma Ogawa, Atsushi Ishizaki
Jul 18, 2015·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Sarah J ChittendenGlenn D Flux
Mar 3, 2017·Chemical & Pharmaceutical Bulletin·Kazuma OgawaAkira Odani

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Software Mentioned

GraphPad
Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.