Dectin-1-Syk-CARD9 Signaling Pathway in TB Immunity

Frontiers in Immunology
Matthew WagenerMohlopheni Jackson Marakalala

Abstract

One of the first steps toward mounting an effective immune response to Mycobacterium tuberculosis (Mtb) is recognition of the pathogen through pattern-recognition receptors (PRRs) expressed by innate immune cells. Activation of the PRR Dectin-1 by an unknown mycobacterial ligand triggers an intracellular signaling cascade involving numerous proteins, including spleen tyrosine kinase, protein kinase C-delta, and caspase recruitment domain family member 9, some of which have been shown to influence host immune response to TB infection. Here, we review the role of Dectin-1 signaling pathway in anti-mycobacterial immunity and discuss its contribution in the control of Mtb infection, and potential applications in TB vaccine adjuvanticity.

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Citations

Nov 2, 2019·Ocular Immunology and Inflammation·Fuzhen LiPeizeng Yang
Nov 14, 2019·The Journal of Biological Chemistry·Tejasvi K DasariThirumala-Devi Kanneganti
Nov 15, 2019·Biochemical Society Transactions·Mariano Prado Acosta, Bernd Lepenies
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Dec 12, 2020·Journal of Cellular Physiology·Shiika HaraWataru Ariyoshi
Feb 2, 2021·Frontiers in Microbiology·Eli Isael MacielNéstor J Oviedo
Feb 16, 2021·Immunobiology·Namarta KaliaManpreet Kaur
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Methods Mentioned

BETA
glycosylation
gene knockout
gene knockouts

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