Decursin from Angelica gigas suppresses RANKL-induced osteoclast formation and bone loss

European Journal of Pharmacology
Xin WangMijung Yim

Abstract

Osteoclasts are the only cells capable of breaking down bone matrix, and excessive activation of osteoclasts is responsible for bone-destructive diseases. In this study, we investigated the effects of decursin from extract of Angelica gigas root on receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclast formation using mouse bone marrow-derived macrophages (BMMs). Decursin inhibited RANKL-induced osteoclast formation without cytotoxicity. In particular, decursin maintains the characteristics of macrophages by blocking osteoclast differentiation by RANKL. Furthermore, the RANKL-stimulated bone resorption was diminished by decursin. Mechanistically, decursin blocked the RANKL-triggered ERK mitogen-activated protein kinases (MAPK) phosphorylation, which results in suppression of c-Fos and the nuclear factor of activated T cells (NFATc1) expression. In accordance with the in vitro study, decursin reduced lipopolysaccharide (LPS)- or ovariectomy (OVX)-induced bone loss in vivo. Therefore, decursin exerted an inhibitory effect on osteoclast formation and bone loss in vitro and in vivo. Decursin could be useful for the treatment of bone diseases associated with excessive bone resorption.

References

Sep 29, 1999·Genes & Development·W C DougallJ Schuh
May 16, 2003·Nature·William J BoyleDavid L Lacey
Mar 31, 2004·Molecular Aspects of Medicine·Virginia B C JunqueiraGuilherme P Deucher
Apr 10, 2004·The Journal of Biological Chemistry·Koichi MatsuoErwin F Wagner
Aug 18, 2004·The Journal of Clinical Investigation·Fumiyo IkedaToshiyuki Yoneda
Nov 9, 2004·Experimental Cell Research·Hyunil HaZang Hee Lee
Jan 26, 2005·The Journal of Clinical Investigation·Shi WeiSteven L Teitelbaum
Feb 23, 2005·Current Drug Targets. CNS and Neurological Disorders·James W SimpkinsJames A Dykens
Jul 14, 2005·IUBMB Life·Xu Feng
Aug 17, 2005·Current Drug Targets. Inflammation and Allergy·Yoshiya TanakaYosuke Okada
Nov 14, 2006·Bone·Masataka Asagiri, Hiroshi Takayanagi
Mar 24, 2007·Nature Reviews. Immunology·Hiroshi Takayanagi
Apr 4, 2007·The Journal of Biological Chemistry·Sudarshana M SharmaMichael C Ostrowski
Nov 28, 2007·Annual Review of Pathology·Deborah V Novack, Steven L Teitelbaum
Dec 17, 2008·Annals of the New York Academy of Sciences·Andreas Leibbrandt, Josef M Penninger

❮ Previous
Next ❯

Citations

Jan 23, 2017·International Journal of Biological Macromolecules·Hyun Woo LeeHoon Kim
Nov 15, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Adeeb ShehzadYoung Sup Lee
Apr 13, 2021·Frontiers in Pharmacology·La Yoon ChoiWoong Mo Yang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.