Decursin inhibits induction of inflammatory mediators by blocking nuclear factor-kappaB activation in macrophages

Molecular Pharmacology
Jung-Hee KimWon-Ha Lee

Abstract

In the course of screening inhibitors of matrix metalloproteinase (MMP)-9 induction in macrophages, we isolated decursin, a coumarin compound, from the roots of Angelicae gigas. As a marker for the screening and isolation, we tested expression of MMP-9 in RAW264.7 cells and THP-1 cells after treatment with bacterial lipopolysaccharide (LPS), the TLR-4 ligand. Decursin suppressed MMP-9 expression in cells stimulated by LPS in a dose-dependent manner at concentrations below 60 microM with no sign of cytotoxicity. The suppressive effect of decursin was observed not only in cells stimulated with ligands for TLR4, TLR2, TLR3, and TLR9 but also in cells stimulated with interleukin (IL)-1beta, and tumor necrosis factor (TNF)-alpha, indicating that the molecular target of decursin is common signaling molecules induced by these stimulants. In addition to the suppression of MMP-9 expression, decursin blocked nitric oxide production and cytokine (IL-8, MCP-1, IL-1beta, and TNF-alpha) secretion induced by LPS. To find out the molecular mechanism responsible for the suppressive effect of decursin, we analyzed signaling molecules involved in the TLR-mediated activation of MMP-9 and cytokines. Decursin blocked phosphorylation of IkappaB and n...Continue Reading

References

Jan 1, 1994·Annals of the Rheumatic Diseases·G YanniB Bresnihan
Jan 1, 1996·Arthritis and Rheumatism·D MulherinB Bresnihan
Jan 14, 1999·The New England Journal of Medicine·R Ross
Jul 28, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S T HolgateA F Walls
Nov 30, 2000·Arthritis Research·R W KinneG R Burmester
May 16, 2002·Current Rheumatology Reports·Margriet J B M Vervoordeldonk, Paul P Tak
Dec 12, 2002·Current Opinion in Pulmonary Medicine·Elizabeth A Kelly, Nizar N Jarjour
Dec 20, 2002·Nature·Peter Libby
Dec 24, 2002·American Journal of Respiratory Cell and Molecular Biology·Jeffrey J Atkinson, Robert M Senior
Oct 17, 2003·Archives of Pharmacal Research·Sanghyun LeeSam Sik Kang
Nov 19, 2003·Molecular and Cellular Biochemistry·Sajal ChakrabortiTapati Chakraborti
Jan 24, 2004·Heart Failure Reviews·Matthias PauschingerHeinz-Peter Schultheiss
Mar 17, 2004·Current Atherosclerosis Reports·Noboru Watanabe, Uichi Ikeda
May 26, 2004·Critical Reviews in Oncology/hematology·G KleinE S J M de Bont
Jun 4, 2004·Treatments in Respiratory Medicine·Ryujiro SuzukiHiroyuki Taniguchi
Jun 30, 2004·Scandinavian Journal of Clinical and Laboratory Investigation·J RenkoS T Nikkari
Sep 17, 2004·Cell·Hans Clevers
Oct 19, 2004·Seminars in Cancer Biology·Mary PhilipHans Schreiber
Feb 1, 2005·Journal of Natural Products·So Young KangYoung Choong Kim
May 17, 2005·Current Cancer Drug Targets·Pia VihinenVeli-Matti Kähäri
Jun 25, 2005·Current Cancer Drug Targets·F MannelloS Papa

❮ Previous
Next ❯

Citations

Jan 15, 2013·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Eun-Ju KimWon-Ha Lee
Aug 29, 2007·Acta Pharmacologica Sinica·Junxuan LuJunming Guo
Feb 7, 2014·BMC Complementary and Alternative Medicine·Ji Sun HwangSin-Hyeog Im
Jan 7, 2014·Chemical & Pharmaceutical Bulletin·Miwa KuboYoshiyasu Fukuyama
Jan 12, 2007·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Xiu-wei YangJing-rong Cui
Dec 18, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·You-Chang OhJin Yeul Ma
Mar 29, 2013·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·G A BonaterraR Kinscherf
Mar 29, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Tae Ho ChungJin Yeul Ma
Apr 21, 2016·Journal of Neuroinflammation·Gyun Jee SongKyoungho Suk
Dec 6, 2012·Journal of Ethnopharmacology·Ji Sun HwangSin-Hyeog Im
Jun 24, 2010·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·G A BonaterraR Kinscherf
Jun 19, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Youngjoo SohnHyuk-Sang Jung
Jan 13, 2017·Preventive Nutrition and Food Science·Jaeyong KimChul-Yung Choi
Sep 5, 2017·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Mamoru Fukuchi
Sep 18, 2013·The World Journal of Men's Health·Byung Il YoonSae Woong Kim
Sep 12, 2012·Molecular Medicine Reports·Ying LiuPei-bo Li
Dec 13, 2012·International Journal of Molecular Medicine·Bo-Mi HwangYoung-Rae Lee
Nov 14, 2012·Phytotherapy Research : PTR·Dev S ChahalMohan R Dasu
Sep 23, 2020·Pharmacology Research & Perspectives·Jingyi ZhaoRongxin Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.