PMID: 32538763Jun 17, 2020Paper

Decursin inhibits the oxidation of low-density lipoprotein and protects human aortic endothelial cells against oxidative damage.

Cellular and Molecular Biology
Xueting WangYuling Yang

Abstract

Atherosclerosis is the pathological basis of cardiovascular diseases (CVDs) which are the leading cause of death worldwide. The pathogenesis of atherosclerosis itself is complex. Low-density lipoprotein (LDL) oxidation has been shown to increase lipid peroxide levels in arterial wall of atherosclerosis lesion site. Decursin is a coumarin with a range of pharmacological effects. The present study investigated the inhibitory effect of decursin on LDL oxidation, and its protective effect against oxidative damage in human aortic endothelial cells (HAECs). Two models of oxidative damage were used in this study: Cu2+-induced LDL oxidative damage and 2,2'-azobis-2-methyl-propanimidyl, dihydrochloride (AAPH)-induced oxidative damage of HAECs. The inhibitory effect of decursin on LDL oxidation, and its protective effect on oxidative damage of HAECs were determined. The results showed that the level of thiobarbituric acid reactive substances (TBARS) was significantly increased by Cu2+, but was significantly and concentration-dependently reduced after treatment with decursin (p < 0.05). There were only a few viable cells in AAPH-treated group, but treatment with decursin led to significant, time- and concentration-dependent increases i...Continue Reading

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