Dedifferentiated chondrosarcoma arising in a solitary osteochondroma with leiomyosarcomatous component: a case report

Archives of Orthopaedic and Trauma Surgery
Tsutomu AkahaneHiroyuki Kato

Abstract

A rare variant of dedifferentiated chondrosarcoma with leiomyosarcomatous component in a 63-year-old male is reported. He had a life-long osteochondroma adjacent to the left knee and recently developed swollen and pain. We initially suspected an intermediate grade chondrosarcoma arising in a solitary osteochondroma, but a biopsy specimen revealed a dedifferentiated component that histologically was classified as leiomyosarcoma. Multiple lung metastases were also present. The patient underwent amputation above knee and lung operation following adjuvant chemotherapy, but he died because of pulmonary metastasis 2 years after first admission. The differentiated component usually shows the histological features of osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. Among the rare dedifferentiation with leiomyosarcomatous component, case arising in a solitary osteochondroma is not reported yet.

References

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Citations

Jul 28, 2009·Archives of Orthopaedic and Trauma Surgery·Jae Ho YooJang Gyu Cha
Sep 8, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Leida B RozemanPancras Cw Hogendoorn
Mar 1, 2012·Surgical Pathology Clinics·Scott E Kilpatrick
Nov 11, 2009·Pathology·Kavita KohliNita Khurana
Jun 28, 2012·International Journal of Surgical Pathology·Jin HuangHuizhen Zhang
Jan 8, 2021·Skeletal Radiology·Rupert BerkeleyAsif Saifuddin
May 30, 2021·Seminars in Diagnostic Pathology·Iva Brčić, Andrew E Rosenberg

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