PMID: 8944047Dec 1, 1996Paper

Dedifferentiated liposarcoma of the subcutis

The American Journal of Surgical Pathology
H YoshikawaH Fukuda

Abstract

This report describes an 82-year-old woman with dedifferentiated liposarcoma, an extremely rare neoplasm of the subcutis. The patient had first recognized a very soft mass in the anterolateral part of the right thigh more than 20 years earlier, but because the tumor showed little change over this period, she did not seek treatment. She recently noticed a hard, rapidly growing mass within the former tumor. Both magnetic resonance imaging and axial computed tomography revealed a subcutaneous fatty lesion measuring 12 x 7 x 4 cm and a well-delineated mass-like area (4 x 3 x 3 cm) of nonfatty tissue within the lesion. Histologically, the former was a mature lipomatous tumor with broad fibrous septa containing some atypical stromal cells, and the latter was a much more cellular, spindle cell tumor with a malignant fibrous histiocytoma-like pattern. The authors propose that dedifferentiated liposarcoma is not restricted to the deep soft tissues and may develop in the subcutis and further suggest appropriate surgical management for well-differentiated fatty tumors of subcutaneous origin.

References

Dec 1, 1979·The American Journal of Surgical Pathology·H L Evans
Feb 11, 1992·The American Journal of Surgical Pathology·L M WeissH F Frierson
Mar 1, 1987·The American Journal of Surgical Pathology·N AzumiM R Hendrickson
Nov 1, 1994·American Journal of Clinical Pathology·D R LucasM G Rock
Nov 1, 1994·The American Journal of Surgical Pathology·H L EvansA G Ayala
Jun 1, 1993·The American Journal of Surgical Pathology·G TalliniJ M Woodruff
Jul 1, 1993·AJR. American Journal of Roentgenology·M J KransdorfJ S Jelinek

❮ Previous
Next ❯

Citations

Nov 1, 2001·Cancer Chemotherapy and Biological Response Modifiers·J Verweij
Aug 13, 1998·The American Journal of Dermatopathology·A P Dei TosC D Fletcher
Sep 15, 2005·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Mark D MurpheyJulie Fanburg-Smith
Aug 2, 2011·Orthopedics·Flavia A SakamotoMurali Sundaram
Jun 3, 2008·The Surgical Clinics of North America·Julie M Wu, Elizabeth Montgomery
Dec 23, 2004·Annals of Diagnostic Pathology·Gustavo de la RozaSeena C Aisner
Nov 6, 2004·Cancer Genetics and Cytogenetics·Avery A Sandberg
Jun 27, 1998·Pathology·P W AllenL B MacCormac
May 13, 2006·Annales de chirurgie plastique et esthétique·K El HamdouchiB Hassam
Aug 13, 2004·International Journal of Surgical Pathology·Karl T K Chen
Aug 1, 2015·Arkhiv patologii·E V ZolotarevaV I Rodionov
Jun 11, 1999·Journal of Surgical Oncology·E Montgomery, R Buras

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.