PMID: 9181367May 1, 1997Paper

Dedifferentiated myxoid liposarcoma: a clinicopathological study suggesting a closer relationship between myxoid and well-differentiated liposarcoma

Histopathology
T Mentzel, C D Fletcher

Abstract

Myxoid/round cell liposarcoma is arguably the commonest type of liposarcoma occurring in the extremities and may show gradual progression from low-grade, pure myxoid liposarcoma to high-grade round cell liposarcoma. Rarely myxoid/round cell liposarcoma is associated with areas of well-differentiated or pleomorphic liposarcoma (mixed liposarcoma). We describe the clinicopathological features of three unusual myxoid/round cell liposarcomas which showed morphological features of de novo dedifferentiation. All patients were male and were aged 66, 70 and 76 years, respectively. One lesion each arose in the retroperitoneum, inguinal region and peritoneal cavity. Histologically, in one case the myxoid/round cell component was juxtaposed to a high-grade non-lipogenic component resembling non-pleomorphic storiform 'malignant fibrous histiocytoma' ('MFH'), one case showed a combination of myxoid liposarcoma and a high-grade myxofibrosarcoma-like component (so-called myxoid 'MFH'), and in the third case, a well-differentiated myxoid liposarcoma with a discontinuous micronodular pattern of dedifferentiation was seen. Follow-up information of 30, 28 and 26 months revealed two recurrences each in two patients. These patients died of postoper...Continue Reading

Citations

Jun 26, 2001·Histopathology·A Al-Nafussi, N A Wong
Jan 8, 1999·Japanese Journal of Clinical Oncology·A SaitoY Moriya
Sep 23, 2003·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Pascale Hummel LevineStephanie V Blank
Feb 6, 2009·The American Journal of Surgical Pathology·Rita AlaggioAndrew L Folpe
Jun 4, 2008·Sarcoma·J F Van Roggen, P C Hogendoorn
May 11, 2012·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Cheryl M Coffin, Rita Alaggio
Jun 13, 2012·Journal of Radiology Case Reports·Garth S CampbellLuminita Rezeanu
Jan 21, 2014·Indian Journal of Pathology & Microbiology·Shashikant C U PatneManoj Pandey
Feb 13, 2001·Journal of Clinical Periodontology·G FaviaA Piattelli
Sep 12, 2000·Applied Immunohistochemistry & Molecular Morphology : AIMM·S PilottiM A Pierotti
May 29, 2004·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Hirofumi NakanishiHideki Yoshikawa
Jul 27, 2007·Acta Oncologica·Katarina EngströmJeanne M Meis-Kindblom
Sep 21, 2011·Diagnostic Cytopathology·Leslie G Dodd
Jul 15, 2011·Journal of Cutaneous Pathology·Justin P BandinoDonald J Grande
Nov 6, 2004·Cancer Genetics and Cytogenetics·Avery A Sandberg
Apr 4, 2006·Pathology·Jeung Il KimMee Young Sol
Mar 10, 2015·Applied Immunohistochemistry & Molecular Morphology : AIMM·Noëlle WeingertnerJean-Pierre Ghnassia
Jul 9, 2011·Otolaryngologia polska. The Polish otolaryngology·Zyłka StanisławOkła Sławomir
Nov 19, 2009·Acta Orthopaedica. Supplementum·Thor AlvegårdAnders Rydholm
Mar 9, 1999·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·H HasegawaS Eda
May 13, 2021·Journal of Clinical Pathology·Yuichi YamadaYoshinao Oda

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