Dedifferentiated Solitary Fibrous Tumor: A Concise Review

Archives of Pathology & Laboratory Medicine
Nicholas J Olson, Konstantinos Linos

Abstract

Solitary fibrous tumor (SFT) is a unique mesenchymal neoplasm that was originally believed to be of submesothelial origin. Eventually, SFT expanded to include what was previously called hemangiopericytoma in other regions of the body that had similar immunohistochemical and morphologic features. Although most are benign, many studies have tried to identify histologic features that predict which tumors will behave in an aggressive manner. Recently, dedifferentiation has been described in rare cases of SFT and does appear to correlate with a more aggressive clinical course. Dedifferentiated SFT occurs in a similar age range and location as conventional SFT and can resemble multiple different malignant entities. Utilization of ancillary studies and thorough tissue sampling is important to reach the correct diagnosis. The morphologic features, immunohistochemistry, molecular alterations, and prognosis will be discussed.

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Oct 28, 2018·BMJ Case Reports·Mariana Nogueira SantosHelena Baldaia
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Dec 1, 2021·Cancer Control : Journal of the Moffitt Cancer Center·Jin YuanShengji Yu

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