Deep brain stimulation does not enhance neuroinflammation in multiple system atrophy

Neurobiology of Disease
Miguel Lopez-CuinaWassilios G Meissner

Abstract

Slowly progressive, levodopa-responsive multiple system atrophy (MSA) may be misdiagnosed as Parkinson's disease (PD). Deep brain stimulation (DBS) is mostly ineffective in these patients and may even worsen the clinical course. Here we assessed whether neuropathological differences between patients with MSA who were treated with DBS of the subthalamic nucleus because of a misleading clinical presentation and typical disease cases may explain the more benign disease course of the former, and also the rapid clinical decline after surgery. The post-mortem assessment included the subthalamic nucleus, the globus pallidus, the thalamus and the putamen in five patients with MSA who received DBS and nine typical disease cases. There was no evidence for distinct neuroinflammatory profiles between both groups that could be related to the surgical procedure or that could explain the rapid clinical progression during DBS. Patients who received deep brain stimulation displayed a higher proportion of α-synuclein bearing neuronal cytoplasmic inclusions in the putamen compared with typical cases, while the number of surviving neurons was not different between groups. Our findings suggest that DBS does not induce neuroinflammatory changes in p...Continue Reading

Citations

Nov 7, 2019·Movement Disorders : Official Journal of the Movement Disorder Society·Wassilios G MeissnerOlivier Rascol
Dec 10, 2020·Journal of Clinical Medicine·Carlo Alberto ArtusiFrancesca Morgante

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